Neural and Müller glial adaptation of the retina to photoreceptor degeneration  

作　　者：Henri O.Leinonen Edward Bull Zhongjie Fu 

机构地区：[1]Faculty of Health Sciences,School of Pharmacy,University of Eastern Finland,Kuopio,Finland [2]Department of Ophthalmology,Boston Children’s Hospital,Harvard Medical School,Boston,MA,USA

出　　处：《Neural Regeneration Research》2023年第4期701-707,共7页中国神经再生研究（英文版）

基　　金：supported by NIH R01EY032492;Boston Children’s Hospital(OFD/BTREC/CTREC Faculty Career Development Grant 97906,Pilot Grant 92214,and Ophthalmology Foundation 85010);Mass Lions Eye Foundation 87820;Blind Children’s Center 89282(to ZF);Academy of Finland grant 346295;Finnish Eye and Tissue Bank Foundation;Retina Registered Association(Finland);Sokeain Yst?v?t/De Blindas V?nner Registered Association(to HOL)。

摘　　要：The majority of inherited retinal degenerative diseases and dry age-related macular degeneration are characterized by decay of the outer retina and photoreceptors,which leads to progressive loss of vision.The inner retina,including second-and third-order retinal neurons,also shows aberrant structural changes at all stages of degeneration.Müller glia,the major glial cells maintain retinal homeostasis,activating and rearranging immediately in response to photoreceptor stress.These phenomena are collectively known as retinal remodeling and are anatomically well described,but their impact on visual function is less well characterized.Retinal remodeling has traditionally been considered a detrimental chain of events that decreases visual function.However,emerging evidence from functional assays suggests that remodeling could also be a part of a survival mechanism wherein the inner retina responds plastically to outer retinal degeneration.The visual system’s first synapses between the photoreceptors and bipolar cells undergo rewiring and functionally compensate to maintain normal signal output to the brain.Distinct classes of retinal ganglion cells remain even after the massive loss of photoreceptors.Müller glia possess the regenerative potential for retinal recovery and possibly exert adaptive transcriptional changes in response to neuronal loss.These types of homeostatic changes could potentially explain the well-maintained visual function observed in patients with inherited retinal degenerative diseases who display prominent anatomic retinal pathology.This review will focus on our current understanding of retinal neuronal and Müller glial adaptation for the potential preservation of retinal activity during photoreceptor degeneration.Targeting retinal self-compensatory responses could help generate universal strategies to delay sensory disease progression.

关 键 词：bipolar cells ELECTRORETINOGRAPHY Müller glia PHOTORECEPTORS plasticity retinal degeneration retinal neuron retinal remodeling retinal ganglion cells 

分 类 号：R774[医药卫生—眼科]