Pathophysiological mechanisms of chronic compressive spinal cord injury due to vascular events  

作　　者：Zhen-Xiao Ren Jing-Hui Xu Xing Cheng Gui-Xing Xu Hou-Qing Long 

机构地区：[1]Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology/Department of Spine Surgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China [2]Department of Neurosurgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China

出　　处：《Neural Regeneration Research》2023年第4期790-796,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81450020(to HQL)。

摘　　要：Cervical spondylotic myelopathy is the main cause of non-traumatic spinal cord injury,with chronic static and/or dynamic compressive spinal cord injury as the unique pathogenesis.In the progression of this condition,the microvascular network is compressed and destroyed,resulting in ischemia and hypoxia.The main pathological changes are inflammation,damage to the blood spinal cord barriers,and cell apoptosis at the site of compression.Studies have confirmed that vascular regeneration and remodeling contribute to neural repair by promoting blood flow and the reconstruction of effective circulation to meet the nutrient and oxygen requirements for nerve repair.Surgical decompression is the most effective clinical treatment for this condition;however,in some patients,residual neurological dysfunction remains after decompression.Facilitating revascularization during compression and after decompression is therefore complementary to surgical treatment.In this review,we summarize the progress in research on chronic compressive spinal cord injury,covering both physiological and pathological changes after compression and decompression,and the regulatory mechanisms of vascular injury and repair.

关 键 词：ANGIOGENESIS cervical spondylotic myelopathy HYPOXIA inflammation ISCHEMIA spinal cord injury surgical decompression 

分 类 号：R651.2[医药卫生—外科学]