蛋白激酶TAOKs生物学功能及其与相关疾病关系的研究进展  

Research Progress on the Biological Functions and the Relevant Diseases of Protein Kinase TAOKs

作　　者：骆晓刚 周俊[1] LUO Xiaogang;ZHOU Jun(Department of Human Anatomy and Tissue Embryology,School of Basic Medical Sciences,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学基础医学院人体解剖和组织胚胎学系,杭州310058

出　　处：《中国细胞生物学学报》2022年第6期1129-1138,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:31870865);浙江省自然科学基金(批准号:LY18H100001);广东省组织器官区域免疫与疾病重点实验室开放基金(批准号:2019B030301009)资助的课题。

摘　　要：蛋白激酶TAOKs(thousand and one amino acid protein kinases)是丝氨酸/苏氨酸蛋白激酶家族成员,属于生发中心激酶(GCK)样类别Ste20样激酶,是一种与细胞骨架稳定性密切相关的蛋白激酶。TAOKs共有三个成员:TAOK1、TAOK2和TAOK3,其结构域均高度保守,广泛表达于多种细胞和组织。作为丝裂原活化蛋白激酶(MAPK)级联的上游激酶,TAOKs通过p38 MAPK和JNK/SAPK等信号通路,调节细胞和组织中重要的生理和病理反应,参与细胞有丝分裂和细胞凋亡等生命过程。研究表明,TAOKs在JNK/SAPK种疾病,例如肿瘤和神经退行性疾病等的发生发展过程中发挥了一定作用,此外,TAOKs也参与免疫细胞的成熟活化和机体炎症反应的调控。该文就TAOKs的生物学功能及其在各种疾病中的研究进展进行了综述,并对其今后潜在的研究方向进行了探讨。The protein kinase TAOKs (thousand and one amino acid protein kinases) are members of the serine/threonine protein kinase family and belong to the GCK-like class of Ste20-like kinases.They are associated with the stability of cytoskeleton.There are three members of TAOKs:TAOK1,TAOK2 and TAOK3.Their domains are highly conserved and are widely expressed in a variety of cells and tissues.As kinases upstream of MAPK cascade,TAOKs regulate important physiological and pathological responses in cells and tissues through p38 MAPK,JNK/SAPK signaling pathways,and they are involved in mitosis as well as cell apoptosis.It has been reported that TAOKs play a role in the pathogenesis of a series of diseases,such as neurodegenerative diseases and tumors.In addition,TAOKs are also involved in the maturation and activation of immune cells and the regulation of inflammatory response.This review summarizes the research progress on the biological functions of TAOKs as well as its role in diseases and discusses the potential research directions of TAOKs in the future.

关 键 词：TAOKs 有丝分裂 肿瘤 微管稳定性 神经退行性疾病 凋亡 免疫 

分 类 号：R363[医药卫生—病理学]