Can physical activity eliminate the mortality risk associated with poor sleep?A 15-year follow-up of 341,248 MJ Cohort participants  

作　　者：Li-Jung Chen Mark Hamer Yun-Ju Lai Bo-Huei Huang Po-Wen Ku Emmanuel Stamatakis 

机构地区：[1]Department of Exercise Health Science,(National)Taiwan University of Sport,Taichung 40404,China [2]Institute of Sport Exercise and Health,Division of Surgery and Interventional Science,Faculty of Medical Sciences,University College London,London,WC1E 6BT,UK [3]Division of Endocrinology and Metabolism,Department of Internal Medicine,Puli Branch of Taichung Veterans General Hospital,Nantou 54552,China [4]School of Medicine,(National)Yang-Ming University,Taipei 11221,China [5]Charles Perkins Centre,School of Health Sciences,Faculty of Medicine and Health,University of Sydney,Sydney,NSW 2006,Australia [6]Graduate Institute of Sports and Health,(National)Changhua University of Education,Changhua 50007,China [7]Department of Kinesiology,(National)Tsing Hua University,Hsinchu 30013,China

出　　处：《Journal of Sport and Health Science》2022年第5期596-604,共9页运动与健康科学（英文）

基　　金：PWK’s work is supported in part by the Ministry of Science and Technology (MOST 108-2410-H-018-028-MY3);funded by the National Health and Medical Research Council(NHMRC) through a Senior Research Fellowship。

摘　　要：Background:This study examined the joint associations of sleep patterns and physical activity(PA) with all-cause,cardiovascular disease(CVD),and cancer mortality.Methods:A total of 341,248 adults(mean age=39.7 years;men:48.3%) were included in the study,with a 15-year follow-up.Participants reported sleep duration and disturbances(difficulty falling asleep,easily awakened,or use of sleeping medication).PA was classified into 4 levels:<7.5,7.5-14.9,15.0-29.9,and>30.0 metabolic equivalent hours per week(MET-h/week).To understand the joint associations of sleep patterns and PA with mortality,Cox proportional hazard models were conducted,with exposure variables combining sleep duration/disturbances and PA.Results:Compared with the reference group(sleeping 6-8 h/day),individuals who slept>8 h/day had higher risk for all-cause mortality(hazard ratio(HR)=1.307,95% confidence interval(95%CI):1.248-1.369),CVD mortality(HR=1.298,95%CI:1.165-1.445),and cancer mortality(HR=1.128,95%CI:1.042-1.220).Short sleep duration was not associated with mortality risk.Increased risk of all-cause and CVD mortality was found in participants who had difficulty falling asleep(HR=1.120,95%CI:1.068-1.175;HR=1.163,95%CI:1.038-1.304,respectively),and used sleeping medication(HR=1.261,95%CI:1.159-1.372;HR=1.335,95%CI:1.102-1.618,respectively) compared with those who slept well.Long sleep duration and sleep disturbances were not associated with risk of all-cause and CVD mortality among individuals achieving a PA level of>15 MET-h/week,and in particular among those achieving> 30 MET-h/week.Conclusion:Long sleep duration,difficulty falling asleep,and use of sleeping medication were related to a higher risk of death.Being physically active at a moderate intensity for 25-65 min/day eliminated these detrimental associations.

关 键 词：Exercise Heart disease INACTIVITY INSOMNIA Sleep disorders 

分 类 号：R740[医药卫生—神经病学与精神病学]