COVID-19 infection with keratitis as the first clinical manifestation  

作　　者：Dong-Mei Zuo Lin-Ping Xue Heng Fan Sheng-Li Yang Liang-Chang Li Ji-Hong Luo Shuo Zang Jun Xiao 

机构地区：[1]Department of Integrated Traditional Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China [2]First Clinical College of Hubei University of Traditional Chinese Medicine,Wuhan 430061,Hubei Province,China [3]Department of Oncology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China [4]Department of Ophthalmology,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430061,Hubei Province,China [5]The Macrohard Institute of Health,231 North Ave,Battle Creek,MI 49017,USA

出　　处：《International Journal of Ophthalmology(English edition)》2022年第9期1544-1548,共5页国际眼科杂志（英文版）

基　　金：Supported by the Tongji-Rockcheck Life Science and Medicine Research Center(No.202014)。

摘　　要：·AIM:To report a case which keratitis is the first clinical manifestation of COVID-19 that occurred 3 d earlier than the common COVID-19 symptoms.·METHODS:Regular slit lamp examination,corneal scraping test,and chest computed tomography(CT)were performed for patients with COVID-19 infection.The ophthalmologic treatment included ganciclovir eye drop(50 mglmL,6 times/d).The treatment for diarrhea included Guifu Lizhong pills(TID).The antiviral therapy consisted of oseltamivir(75 mg capsule Q12 H);therapy preventing bacterial infection consisted of azithromycin(250 mg tablet QD)and moxifloxacin(0.4 g tablet Q12 H);and therapy for cough relief and fever prevention consisted of Chinese herbal decoction.·RESULTS:A 35-year-old male suddenly suffered pain,photophobia,and tears in his right eye for one day without systemic COVID-19 symptoms.Patient was diagnosed with keratitis,which was seemingly different from common keratitis.Ganciclovir eye drop was initiated.The corneal scraping test for COVID-19 was positive.The chest CT images were abnormal confirming the diagnosis of COVID-19 infection.The antiviral and antibacterial therapies were initiated.Chinese herbal therapy was used for cough relief and fever prevention.After roughly two weeks,patient recovered from COVID-19.·CONCLUSION:A new type of keratitis,atypical keratitis,is a clinical manifestation of COVID-19,and this clinical manifestation could appear 3 d earlier than fever and cough.The earlier a COVID-19 clinical manifestation is identified,the earlier can a patient be directed to stay at home,and significantly fewer people would be infected.

关 键 词：KERATITIS first clinical manifestation COVID-19 atypical keratitis 

分 类 号：R772.21[医药卫生—眼科] R563.1[医药卫生—临床医学]