食品蛋白来源的降血糖肽的研究进展  

Research progress of hypoglycemic peptides derived from food protein

作　　者：张晓艺 王晗 裴栋[2,3] 王宁丽 邸多隆[2,3] 刘晓风 魏鉴腾[2,3,4] ZHANG Xiao-yi;WANG Han;PEI Dong;WANG Ning-li;DI Duo-long;LIU Xiao-feng;WEI Jian-teng(School of Life Science and Engineering,Lanzhou University of Technology,Lanzhou 730050,China;Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory of Natural Medicine of Gansu Province,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China;Qingdao Resource Chemistry and New Materials Research Center,Qingdao 266100,China;Yantai Zhongke Advanced Materials and Green Chemical Industry Technology Research Institute,Yantai 264001,China)

机构地区：[1]兰州理工大学生命科学与工程学院,甘肃兰州730050 [2]中国科学院兰州化学物理研究所中国科学院西北特色植物资源化学重点实验室和甘肃省天然药物重点实验室,甘肃兰州730000 [3]青岛市资源化学与新材料研究中心,山东青岛266100 [4]烟台中科先进材料与绿色化工产业技术研究院,山东烟台264001

出　　处：《生物技术》2022年第4期528-535,505,共9页Biotechnology

基　　金：中国科学院“西部之光”人才培养引进计划;烟台中科先进材料与绿色化工产业技术研究院项目(AMGCE016);青岛市科技惠民示范引导专项(20-3-4-11-nsh)。

摘　　要：从食品蛋白中发现和制备降血糖肽对于辅助治疗糖尿病具有很大的应用潜力。该文将整合降糖肽的制备方法、分离纯化方法、结构鉴定方法,以及阐述其作用机制的最新研究进展,并介绍潜在健康益处和未来发展方向。分析显示通过多酶复合水解和超滤、各种色谱法进行提取和纯化,然后利用色谱技术结合适当的检测器对降糖肽进行鉴定,可以得到含量和生物活性都比较高的降血糖肽。食品蛋白来源的降血糖肽研究的未来前景应集中于寻找具有更高选择性和分辨率的分离纯化技术,以高产率和低成本获得更多新的降血糖肽。此外,需要通过临床试验来证实体内外模型所呈现的健康益处,来实现从工作台到临床的技术转移。The discovery and preparation of hypoglycemic peptides from food proteins has great application potential for adjuvant treatment of diabetes.Here,this article will integrate hypoglycemic peptides The preparation method,separation and purification method,structure identification method,and the latest research progress explaining its mechanism of action,and introduce the potential health benefits and future development directions.The analysis of the article shows that through multi-enzyme complex hydrolysis,ultrafiltration,and various chromatographic methods for extraction and purification,and then using chromatographic technology combined with appropriate detectors to identify the hypoglycemic peptides,hypoglycemic peptides with relatively high content and biological activity can be obtained.The future prospects of the research on hypoglycemic peptides derived from food proteins should focus on finding separation and purification techniques with higher selectivity and resolution,and obtain more new hypoglycemic peptides with high yield and low cost.In addition,clinical trials are needed to confirm the health benefits presented by the in vivo and in vitro models to realize the technology transfer from the workbench to the clinic.

关 键 词：糖尿病 蛋白来源 肽 降糖作用 

分 类 号：TS201.2[轻工技术与工程—食品科学]