食品中喹诺酮类药物残留检测方法的研究进展  

Research Advances of Detection Methods for Quinolones Residues in Foods

作　　者：包懿[1] 刘斌[1] 刘洋 吕卓 周兰影[1] 崔鸿江[2] BAO Yi;LIU Bin;LIU Yang;LYU Zhuo;ZHOU Lan-Ying;CUI Hong-Jiang(Jilin Province Product Quality Supervision and Inspection Institute,Changchun 130103,China;The Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China)

机构地区：[1]吉林省产品质量监督检验院,长春130103 [2]内蒙古医科大学第二附属医院,呼和浩特010030

出　　处：《分析化学》2022年第10期1444-1455,共12页Chinese Journal of Analytical Chemistry

基　　金：吉林省科技发展计划项目(No.20210509024RQ)资助。

摘　　要：喹诺酮类(Quinolones, QNs)药物是人工合成的一类广谱抗生素,广泛应用于食品生产与加工领域。由于滥用或超量使用,食物中的喹诺酮类药物残留可通过食物链进入人体和环境,引起环境污染,对人类健康造成威胁。因此,对食品中喹诺酮类药物残留的灵敏检测具有非常重要的意义。本文归纳总结了近年来食品中喹诺酮类药物残留检测方法的研究进展,对喹诺酮类药物残留的主要检测技术(包括高效液相色谱法、高效液相色谱-质谱联用法、毛细管电泳法和其它非色谱类检测技术)在食品领域中的应用范围、新型前处理方式的开发与利用、各种净化柱填料的筛选与优化等方面的研究进展进行了评述,对当前喹诺酮类药物检测技术存在的问题进行了总结分析,并讨论了其面临的挑战和未来的发展方向。Quinolones, as a kind of broad-spectrum antibacterial antibiotics synthesized artificially, have been widely used in food production and processing. It is believed that quinolones, unscientific overuse or abuse can pose a major threat to human health and has long-term potential harm to food safety even the whole ecosystem through the food chain. In this review, the research advances of detection methods(including high performance liquid chromatography, high performance liquid chromatography-mass spectrometry, capillary electrophoresis and other non-chromatography detection technology) for quinolones residues in foods in recent years were introduced, and the broaden application scope in food detection, development and utilization of new pretreatment methods, selection and optimization of various purification fillers and how to reduce the interference of matrix effect were summarized. The challenges and prospect of the detection techniques for quinolones were also discussed.

关 键 词：食品 喹诺酮类 药物残留 检测方法 评述 

分 类 号：TS207.5[轻工技术与工程—食品科学] O652[轻工技术与工程—食品科学与工程]