Retrotransposons in pluripotent stem cells  

作　　者：Jingwen Wang Junjiu Huang Guang Shi 

机构地区：[1]School of Life Sciences,SunYat-sen University,Guangzhou 510275,P.R.China [2]Key Laboratory of Reproductive Medicine of Guangdong Province,School of Life Sciences and the First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510275,China [3]Key Laboratory of Reproductive Medicine of Guangdong Province,Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China

出　　处：《Cell Regeneration》2020年第1期17-26,共10页细胞再生（英文）

基　　金：This work was supported by the National Key R&D Program of China(2017YFA0102801 and 2017YFC1001901);the National Natural Science Foundation(31671540and 31971365);the Natural Science Foundation of Guangdong Province(2017A030313093 and 2017A030313491);the Guangdong Basic and Applied Basic Research Foundation(2019A1515011422);the Guangzhou Science and Technology Project(201803010020。

摘　　要：Transposable elements constitute about half of the mammalian genome,and can be divided into two classes:the class I(retrotransposons)and the class II(DNA transposons).A few hundred types of retrotransposons,which are dynamic and stage specific,have been annotated.The copy numbers and genomic locations are significantly varied in species.Retrotransposons are active in germ cells,early embryos and pluripotent stem cells(PSCs)correlated with low levels of DNA methylation in epigenetic regulation.Some key pluripotency transcriptional factors(such as OCT4,SOX2,and NANOG)bind retrotransposons and regulate their activities in PSCs,suggesting a vital role of retrotransposons in pluripotency maintenance and self-renewal.In response to retrotransposons transposition,cells employ a number of silencing mechanisms,such as DNA methylation and histone modification.This review summarizes expression patterns,functions,and regulation of retrotransposons in PSCs and early embryonic development.

关 键 词：RETROTRANSPOSON Pluripotent stem cells PLURIPOTENCY Epigenetic regulation 

分 类 号：R73[医药卫生—肿瘤]