Engineered Fabrication of Enamel-Mimetic Materials  

作　　者：Lingyun Zhang Yunfan Zhang Tingting Yu Liying Peng Qiannan Sun Bing Han 

机构地区：[1]Department of Orthodontics,Peking University School and Hospital of Stomatology&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology,Beijing 100081,China

出　　处：《Engineering》2022年第7期113-123,共11页工程（英文）

基　　金：the National Natural Science Founda-tion of China(51972005,51672009,and 51903003).

摘　　要：Tooth enamel,which is a biological tissue mainly composed of well-aligned hydroxyapatite nanocrystals and an interlaced protein matrix,has remarkable mechanical and aesthetic behaviors.Nevertheless,it is challenging to regenerate enamel naturally,and potential pulp involvement and tooth loss may occur.As the hardest biogenic composite material,enamel has long been regarded as a promising load-bearing material.Thus,understanding the enamel formation process and enamel structural motif mechanisms is important for the design and engineering of high-performance biomimetic composites with high strength and physical resilience.Extensive studies have been conducted on mimicking the microstructure and mechanical properties of tooth enamel,and various enamel-like material synthesis protocols have been developed.In light of the engineering fabrication of enamel-like materials,this review focuses on recent progress in synthetic strategies for enamel-mimetic materials and provides a discussion of the potential applications of these materials.

关 键 词：REGENERATION REMINERALIZATION Abiotic enamel BIOMIMETIC 

分 类 号：R783.1[医药卫生—口腔医学] TQ173.7[医药卫生—临床医学]