Treatment of gastric cancer with dermatomyositis as the initial symptom:Two case reports and review of literature  

作　　者：Xiang-Fei Sun Xiao-Dong Gao Kun-Tang Shen 

机构地区：[1]Department of General Surgery,Zhongshan Hospital,Fudan University School of Medicine,Shanghai 200032,China

出　　处：《World Journal of Clinical Cases》2022年第27期9727-9733,共7页世界临床病例杂志

基　　金：Supported by the National Natural Science Foundation of China,No. 81773080。

摘　　要：BACKGROUND Dermatomyositis(DM) is a rare autoimmune disease involving the connective tissue.The association between DM and gastric cancer remains unclear.Patients with DM have an increased risk of cancer and higher mortality.It requires immunosuppressive therapy,heightened surveillance,and immunologic response to internal malignancy.CASE SUMMARY Two cases of gastric cancer with DM as the first symptom in Zhongshan Hospital,Fudan University(Shanghai,China) were reported.Two patients had a typical skin rash.The rash in the first patient involved mainly bilateral upper limbs and neck,while the second patient manifested rash associated mainly with the face,neck,and back.Both manifested muscle weakness in the extremities and elevated serum creatine kinase.Radical resection of the tumor dramatically improved DMrelated symptoms in the two patients.The literature review showed that gastric cancer is more commonly associated with DM in middle-aged and older male populations.CONCLUSION The findings suggest the need for comprehensive screening for malignant tumors in patients with DM refractory to long-term pharmacotherapy or hormone manipulation.

关 键 词：Gastric cancer DERMATOMYOSITIS TREATMENT Literature review RASH Case report 

分 类 号：R735.2[医药卫生—肿瘤]