Multiple primary malignancies-hepatocellular carcinoma combined with splenic lymphoma:A case report  

作　　者：Fa-Zong Wu Xiao-Xiao Chen Wei-Yue Chen Qiao-Hong Wu Jian-Ting Mao Zhong-Wei Zhao 

机构地区：[1]Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research,The Fifth Affiliated Hospital of Wenzhou Medical University,Lishui Hospital of Zhejiang University,Lishui 323000,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第28期10130-10135,共6页世界临床病例杂志

基　　金：Supported by the Medical and Health Technology Plan of Zhejiang Province,No.2020KY1086 and No.2022ZH086。

摘　　要：BACKGROUND Primary liver cancer is one of the most common malignant tumours,while primary splenic lymphoma is a rare malignancy.Thus,cases of hepatocellular carcinoma(HCC)combined with splenic lymphoma are extremely rare.CASE SUMMARY We present a 62-year-old woman who was admitted to the Interventional Radiology Department with a lump in the spleen and liver as well as multiple enlarged lymph nodes visible by ultrasound.Contrast-enhanced computed of the abdomen revealed a circular,low-density,shallow mass(approximately 2.6 cm in diameter)in the left intrahepatic lobe and multiple round,low-density shadows in the spleen with clear boundaries(maximum diameter 7.6 cm).Based on the characteristic clinical symptoms and explicit radiological findings,the clinical diagnosis was HCC with metastasis to the liver portal,retroperitoneal lymph nodes,and spleen.After transcatheter arterial chemoembolization and sequential radiofrequency ablation,the-fetoprotein level returned to the normal range,and the hepatitis B cirrhosis improved.In addition,splenic tumour biopsy confirmed the diagnosis of primary malignant lymphoma,which went into remission after chemotherapy.CONCLUSION HCC with primary splenic non-Hodgkin lymphoma is extremely rare and easily misdiagnosed.Better understanding would facilitate early diagnosis,treatment and prognosis.

关 键 词：Multiple primary malignancies Hepatocellular carcinoma SPLENOMEGALY Extra-hepatic primary malignancy Magnetic resonance imaging Primary non-Hodgkin’slymphoma Case report 

分 类 号：R735.7[医药卫生—肿瘤] R733.2[医药卫生—临床医学]