Three-in-one incidence of hepatocellular carcinoma,cholangiocellular carcinoma,and neuroendocrine carcinoma:A case report  

作　　者：Yang Wu Chao-Bang Xie Yi-Huai He Di Ke Qiong Huang Kai-Fei Zhao Rong-Shu Shi 

机构地区：[1]Department of Intervention,The Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China [2]Department of Infection,The Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China [3]Department of Pathology,The Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China

出　　处：《World Journal of Clinical Cases》2022年第29期10575-10582,共8页世界临床病例杂志

基　　金：Supported by Zunyi City Science and Technology Department HZ(2021),No.44。

摘　　要：BACKGROUND Primary hepatic neuroendocrine carcinoma(NEC)is rare,and a combination with hepatocellular carcinoma(HCC)and cholangiocarcinoma(CCA)is extremely rare.To date,only four combination cases have been reported.The present paper describes the fifth patient.CASE SUMMARY A 32-year-old Chinese man with chronic hepatitis B was hospitalized for persistent upper abdominal pain.Abdominal computed tomography(CT)examination revealed a liver mass.The tumor was located in the 7th and 8th segments of the liver,and CT and magnetic resonance imaging findings were consistent with the diagnosis of HCC.Laboratory examinations revealed the following:Alanine aminotransferase,243 U/L;aspartate aminotransferase,167 U/L;alpha-fetoprotein,4519μg/L.Laparoscopic right lobe hepatectomy was performed on the liver mass.Postoperative pathology showed low differentiation HCC plus medium and low differentiation CCA combined with NEC.One month after the surgery,the patient suffered from epigastric pain again.Liver metastasis was detected by CT,and tumor transcatheter arterial chemoembolization was performed.Unfortunately,the liver tumor was progressively increased and enlarged,and after 1 mo,the patient died of liver failure.CONCLUSION This is a rare case,wherein the tumor is highly aggressive,grows rapidly,and metastasizes in a short period.Imaging and laboratory tests can easily misdiagnose or miss such cases;thus,the final diagnosis relies on pathology.

关 键 词：Neuroendocrine carcinoma Hepatocellular carcinoma Mixed neuroendocrine neoplasm Combined hepatocellular-cholangiocarcinoma CHOLANGIOCARCINOMA Cholangiocellular carcinoma Case report 

分 类 号：R735.7[医药卫生—肿瘤] R735.8[医药卫生—临床医学]