Bone marrow metastatic neuroendocrine carcinoma with unknown primary site:A case report and review of the literature  

作　　者：Xue-Bing Shi Wen-Xia Deng Feng-Xiang Jin 

机构地区：[1]Department of Medical Oncology,Tongling People’s Hospital,Tongling 244000,Anhui Province,China [2]Department of Hematology,Tongling People’s Hospital,Tongling 244000,Anhui Province,China

出　　处：《World Journal of Clinical Cases》2022年第30期11074-11081,共8页世界临床病例杂志

摘　　要：BACKGROUND Metastatic neuroendocrine carcinoma(NEC) of bone marrow is uncommon.Here,we report a case of bone marrow metastatic NEC with an unknown primary site.CASE SUMMARY A 73-year-old Chinese woman was admitted to our hospital because marked chest distress and asthma lasting 1 d on March 18,2018.She was initially diagnosed with pulmonary infection,cardiac insufficiency,thrombocytopenia and severe anemia.Following treatment with antibiotic therapy,diuresis and blood transfusion,the patient’s symptoms greatly improved.After bone marrow examinations,the patient was diagnosed with bone marrow metastatic NEC,bone marrow necrosis(BMN) and secondary myelofibrosis(MF).Further imaging workup did not show the primary tumor,we presumed that the primary site might regress spontaneously or merely be unexplored due to lack of positron emission tomography with gallium peptide.Everolimus(10 mg/d) was added to the treatment and the best supportive and symptomatic therapies were also administered.Unfortunately,the patient’s condition continued to deteriorate and she died on May 15,2018.CONCLUSION Bone marrow invasion of NEC is rare and our patient who suffered from bone marrow metastatic NEC as well as secondary BMN and MF had an extremely poor prognosis.Bone marrow biopsy plays an important role in the diagnosis of solid tumors invading bone marrow.

关 键 词：Neuroendocrine neoplasm Bone marrow metastasis Bone marrow necrosis MYELOFIBROSIS EVEROLIMUS Case report 

分 类 号：R733.3[医药卫生—肿瘤]