茶黄素类在应用中的稳定性系统研究  

Theaflavin stability for practical application

作　　者：俞晨秀[1] 孟婵婵 高焕 孙莉 孙益民[3] YU Chen-xiu;MENG Chan-chan;GAO Huan;SUN Li;SUN Yi-min(Department of Pharmacy,Anhui College of Traditional Chinese Medicine,Wuhu 241000,China;Wuhu Food and Drug Inspection Center,Wuhu 241000,China;School of Chemistryl and Materials Science,Anhui Normal University,Wuhu 241000,China)

机构地区：[1]安徽中医药高等专科学校药学系,芜湖241000 [2]芜湖市食品药品检验中心,芜湖241000 [3]安徽师范大学化学与材料科学学院,芜湖241000

出　　处：《武汉轻工大学学报》2022年第5期46-50,共5页Journal of Wuhan Polytechnic University

基　　金：安徽省高校自然科学研究重点项目(编号:KJ2018A0791)。

摘　　要：茶黄素类有着广泛的用途,为了能更好地应用需要全面了解它的稳定性。实验结合已有研究,以茶黄素应用中常见却未研究的条件为研究参数,采用HPLC法测定茶黄素在各条件下的吸收峰面积(响应值mAU),由面积值的保留率来判断其稳定性。结果表明茶黄素在Fe^(3+)、Al^(3+)等离子中,在空气、光照、夏日室温(25~40℃)中均不稳定,在Ca^(2+)、Zn^(2+)等离子中稳定,在抗坏血酸与EDTA组成的稳定溶液中和冰箱冷藏下有一定的稳定性。Theaflavins have a wide range of uses.Understanding its stability is thus important for practical application.High-performance liquid chromatography(HPLC) was used to determine theaflavin stability under various conditions.Greater area under the absorption peak indicated better stability.We found that theaflavins were unstable in Feand Alsolutions, at room temperature, in basic environments, and under light exposure.Theaflavins were more stable in Znor Casolutions, under refrigeration, in ascorbic acid/EDTA solution, and by ultrasound extraction.The findings provide guidelines for the most favorable conditions of theaflavin storage to ensure stability.

关 键 词：茶黄素 稳定性 应用 吸收峰面积 保留率 

分 类 号：R247.1[医药卫生—中医临床基础]