Effects of Aerobic Exercise in Alleviating Depressive Symptoms of Cerebral Ischemic Rats with Sedentary Behavior by Improving Inflammatory Microenvironment in Hippocampus  

作　　者：Qiang REN Hui NIE 

机构地区：[1]Department of Rehabilitation Medicine,Taihe Hospital,Hubei University of Medicine,Shiyan 442000,China

出　　处：《Medicinal Plant》2022年第4期74-77,89,共5页药用植物：英文版

摘　　要：[Objectives]To explore the role and molecular mechanisms of aerobic exercise in post-stroke depression.[Methods]Wistar rats were randomly divided into sham,sedentary and aerobic exercise(Ex)groups.The rats in sedentary and Ex groups received middle cerebral artery occlusion(MCAO)surgery.Aerobic exercise was performed 24 h after MCAO for four weeks in Ex group.The sucrose preference test(SPT),open field test(OFT),tail suspension test(TST)was performed,respectively.The levels of IL-1β,IL-6,TNF-αwere detected by ELISA.[Results]Aerobic exercise successfully prevented depression-like symptom induced by ischemic stroke with sedentary behavior as indicated by significant increase in sucrose preference(P<0.01)during SPT and decrease in immobility time(P<0.01)during FST and TST.Aerobic exercise significantly reduced the high levels of IL-1β,IL-6,TNF-αinduced by ischemic stroke and sedentary behavior in the ischemic hippocampus(P<0.05).[Conclusions]Aerobic exercise after ischemic stroke can reverse depression and improve the inflammatory microenvironment in the hippocampus.

关 键 词：Stroke Depression EXERCISE Inflammation 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]