IgD型多发性骨髓瘤1 例报道并文献复习  

A Case Report of IgD Multiple Myeloma and Literature Review

作　　者：余晓[1] 周一飞[1] 方宝枝[1] 袁慕知[1] 沈秋丹[1] 吕明恩[1] YU Xiao;ZHOU Yi-fei;FANG Bao-zhi;YUAN Mu-zhi;SHEN Qiu-dan;LYU Ming-en(Department of Hematology,Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Suzhou,Jiangsu,215002,China)

机构地区：[1]南京医科大学附属苏州医院,苏州市立医院本部,江苏苏州215002

出　　处：《中国血液流变学杂志》2022年第2期209-212,共4页Chinese Journal of Hemorheology

摘　　要：目的探讨IgD型多发性骨髓瘤(multiple myeloma,MM)的临床特点。方法对1例明确诊断为IgD型MM的患者病例资料进行回顾性分析,并做相关文献的复习。结果该例患者为58岁女性,以肩颈部疼痛起病,血清蛋白电泳阴性,血免疫固定电泳发现IgD-λ型M蛋白,诊断为IgD-λ型MM。接受1个疗程来那度胺联合地塞米松(RD)方案治疗及5个疗程硼替佐米、来那度胺联合地塞米松(RVD)方案治疗后达到严格意义的完全缓解(stringent complete response,sCR)。结论IgD型MM发病率低,检测方法缺乏敏感性。其临床行为虽具有侵袭性,但新药时代的联合治疗使该类患者的预后得到了明显改善。Objective To investigate the clinical characteristics of IgD multiple myeloma(MM).Methods The clinical data of a patient with IgD MM was analyzed,and the relevant literatures were reviewed.Results The 58-year-old woman presented an initial symptom of neck pain and was diagnosed as IgD-λMM.The serum protein electrophoresis was negative,while M protein of IgD-λwas found by blood immunofixation electrophoresis.The patient was treated with one cycle of Lenalidomide in combination with Dexamethasone(RD),and five cycles of Bortezomib in combination with Lenalidomide and Dexamethasone(RVD).Stringent complete response(sCR)was achieved after the whole 6 cycles of treatments.Conclusion IgD MM is a rare subtype of MM characterized by low sensitive detection and aggressive processing course.However,the combination therapy with new medicines has significantly improved the prognosis of the patients.

关 键 词：IGD 多发性骨髓瘤 免疫固定电泳 

分 类 号：R733.3[医药卫生—肿瘤]