Targeting neuroinflammation after therapeutic hypothermia for perinatal hypoxic-ischemic brain injury  

作　　者：Kelly Q.Zhou Joanne O.Davidson 

机构地区：[1]The Department of Physiology,The University of Auckland,Auckland,New Zealand

出　　处：《Neural Regeneration Research》2023年第6期1261-1262,共2页中国神经再生研究（英文版）

基　　金：supported by the Health Research Council of New Zealand (No.1 7/601 to JD);the Marsden Fund (No.17-UOA232 to JD)

摘　　要：Hypoxic-ischemic encephalopathy(HIE)has an incidence of 1-3 in 1000 term births in high-income countries(Zhou et al.,2020).The standard treatment for these infants is therapeutic hypothermia.Although therapeutic hypothermia significantly reduces the risk of death and disability for infants with HIE,it is still only partially protective as up to 45%of infants still develop disability despite treatment(Zhou et al.,2020).The current therapeutic hypothermia protocol is optimal for widespread use in infants with moderate to severe HIE.However,it is possible that a more tailored approach for individual babies,including stratification of the cooling regimen for the severity of HIE and the identification of reliable biomarkers to guide treatment,may improve efficacy in the future.

关 键 词：THERAPEUTIC INFLAMMATION protective 

分 类 号：R651.15[医药卫生—外科学]