Impact of gender-affirming hormone therapy on the development of COVID-19 infections and associated complications:A systematic review  

作　　者：Jennifer J Ferraro Allie Reynolds Sylvia Edoigiawerie Michelle Y Seu Sydney R Horen Amir Aminzada Alireza Hamidian Jahromi 

机构地区：[1]Department of Surgery,Division of Plastic and Reconstructive Surgery,Rush University Medical Center,Chicago,IL 60612,United States [2]Undergraduate Studies,Princeton University,Princeton,NJ 08544,United States [3]Medical School,The University of Chicago Pritzker School of Medicine,Chicago,IL 60637,United States [4]Division of Plastic and Reconstructive Surgery,Temple University Health System,Philadelphia,PA 19140,United States

出　　处：《World Journal of Methodology》2022年第6期465-475,共11页世界方法学杂志

摘　　要：BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can produce a wide range of clinical manifestations from asymptomatic to life-threatening.Various researchers have worked to elucidate the pathogenic mechanisms underlying these variable presentations.Differences in individual responses to systemic inflammation and coagulopathy appear to be modulated by several factors,including sex steroid hormones.Transgender men or non-binary individuals who undergo gender-affirming hormone therapy(GAHT)are a unique population of interest for exploring the androgen-mediated coronavirus disease 2019(COVID-19)hypothesis.As the search for reliable and effective COVID-19 treatments continues,understanding the risks and benefits of GAHT may mitigate COVID-19 related morbidity and mortality in this patient population.AIM To investigate the potential role of GAHT in the development of COVID-19 infections and complications.METHODS This systematic review implemented an algorithmic approach using PRISMA guidelines.PubMed,Scopus,Google Scholar top 100 results,and archives of Plastic and Reconstructive Surgery was on January 12,2022 using the key words“gender”AND“hormone”AND“therapy”AND“COVID-19”as well as associated terms.Non-English articles,articles published prior to 2019(prior to COVID-19),and manuscripts in the form of reviews,commentaries,or letters were excluded.References of the selected publications were screened as well.RESULTS The database search resulted in the final inclusion of 14 studies related to GAHT COVID-19.Of the included studies,only two studies directly involved and reported on COVID-19 in transgender patients.Several clinical trials looked at the relationship between testosterone,estrogen,and progesterone in COVID-19 infected cis-gender men and women.It has been proposed that androgens may facilitate initial COVID-19 infection,however,once this occurs,testosterone may have a protective effect.Multiple clinical studies have shown that low baseline testosterone levels in men with C

关 键 词：COVID-19 TRANSGENDER Gender-affirming hormone therapy Gender affirmation TESTOSTERONE ESTROGEN 

分 类 号：R73[医药卫生—肿瘤]