肠易激综合征与食物不耐受研究进展  

Progress in understanding of relationship between irritable bowel syndrome and food intolerance

作　　者：张向荣 张艳丽[2] Xiang-Rong Zhang;Yan-Li Zhang(School of Clinical Medicine,China-Japan Friendship Hospital,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Gastroenterology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学中日友好医院临床医学院,北京市100029 [2]中日友好医院消化科,北京市100029

出　　处：《世界华人消化杂志》2022年第20期886-891,共6页World Chinese Journal of Digestology

基　　金：国家重点临床专科建设项目,No.2021-QTL-015.

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)是一种常见的功能性胃肠病,越来越多的研究发现食物不耐受参与IBS的发病.大约有三分之二的IBS患者出现过食物不耐受诱发的临床症状,表现为腹痛、腹胀、腹泻或便秘等胃肠道症状,少数患者还会出现循环、呼吸、神经等其他系统症状.目前食物不耐受参与IBS的确切机制尚不完全清楚.常见食物不耐受的类型有乳糖不耐受、麸质不耐受、可发酵的低聚糖、二糖、单糖、多元醇(fermentable oligosaccharides,disaccharides and monosaccharides and polyols,FODMAP)不耐受、组胺不耐受等,其中乳糖不耐受、FODMAP不耐受在IBS患者中更多见.本文对IBS中食物不耐受的类型、食物不耐受参与IBS发病机制及干预治疗进行综述.Irritable bowel syndrome(IBS)is a common functional gastrointestinal disorder,and more and more studies have found that food intolerance is involved in the pathogenesis of IBS.About two-thirds of IBS patients experience clinical symptoms induced by food intolerance,including gastrointestinal symptoms such as abdominal pain,bloating,diarrhea,or constipation.A small number of patients also experience circulatory,respiratory,neurological,and other systemic symptoms.The exact mechanism by which food intolerance is involved in IBS is not fully understood.Common types of food intolerance include lactose intolerance,gluten intolerance,FODMAP intolerance,and histamine intolerance,among which lactose intolerance and FODMAP intolerance are more common in IBS patients.In this paper,we review the types of food intolerance in IBS and the role of food intolerance in the pathogenesis and intervention of IBS.

关 键 词：肠易激综合征 食物不耐受 FODMAP 乳糖不耐受 组胺 麸质 

分 类 号：R574.4[医药卫生—消化系统]