Gut microbiota diversity and composition in predicting immunotherapy response and immunotherapy-related colitis in melanoma patients:A systematic review  

作　　者：Oliver Oey Yu-Yang Liu Angela Felicia Sunjaya Daniel Martin Simadibrata Muhammad Adnan Khattak Elin Gray 

机构地区：[1]Department of Medical Oncology,St John of God Midland Public and Private Hospital,Midland,Perth 6004,WA,Australia [2]School of Medicine,University of Western Australia,Perth 6009,WA,Australia [3]School of Medicine,University of Queensland,Brisbane 4072,QLD,Australia [4]Faculty of Medicine,Tarumanagara University,Jakarta 11440,Indonesia [5]School of Medicine,University of Indonesia,Jakarta 10430,Indonesia [6]Department of Medical Oncology,Fiona Stanley Hospital,Perth 6150,WA,Australia [7]School of Medical Sciences,Edith Cowan University,Perth 6027,WA,Australia [8]Centre for Precision Health,Edith Cowan University,Perth 6027,WA,Australia

出　　处：《World Journal of Clinical Oncology》2022年第11期929-942,共14页世界临床肿瘤学杂志（英文版）

摘　　要：BACKGROUND Gut microbiome(GM)composition and diversity have recently been studied as a biomarker of response to immune checkpoint blockade therapy(ICB)and of ICBrelated colitis.AIM To conduct a systematic review on the role of GM composition and diversity in predicting response and colitis in patients with melanoma treated with ICB.METHODS The review protocol was registered in PROSPERO:CRD42021228018.From a total of 300 studies,nine studies met inclusion criteria.Two studies were phase I clinical trials,while the remainder were prospective observational studies.All but one study has moderate risk of bias.In addition,we conducted a relevant search by Reference Citation Analysis(RCA)(https://www.referencecitationanalysis.com).RESULTS Fecal samples enriched in Firmicutes phylum were associated with good response to ICB,whereas the Bacteroidales family was associated with poor response to ICB.Samples with greater GM diversity were associated with more favorable response to ICB[hazard ratio(HR)=3.57,95%confidence interval=1.02-12.52,P<0.05].Fecal samples with a higher abundance in Firmicutes were more susceptible to ICB-related colitis(P<0.01)whereas samples enriched in Bacteroidetes were more resistant to ICB-related colitis(P<0.05).Overall,there was limited concordance in the organisms in the GM identified to be associated with response to ICB,and studies evaluating GM diversity showed conflicting results.CONCLUSION This highlights the need for further prospective studies to confirm whether the GM could be used as a biomarker and potential intervention to modulate ICB response in melanoma patients.

关 键 词：MELANOMA Gut microbiome MICROBIOTA Immunotherapy Biomarker Immune checkpoint blockade therapy 

分 类 号：R739.5[医药卫生—肿瘤]