香菇多糖提取、结构和生物活性的研究进展  

Research progress of extraction,structure,and biological activity of lentinan

作　　者：朱俊友 李志佳 董赵微 王岸娜[1] 吴立根[1] ZHU Junyou;LI Zhijia;DONG Zhaowei;WANG Anna;WU Ligen(College of Food Science and Engineering,Henan University of Technology,Zhengzhou 450001,China)

机构地区：[1]河南工业大学粮油食品学院,河南郑州450001

出　　处：《河南工业大学学报（自然科学版）》2022年第5期125-136,共12页Journal of Henan University of Technology：Natural Science Edition

基　　金：河南工业大学博士基金项目(2018BS076)。

摘　　要：香菇多糖通常由热水浸提法从香菇子实体中获得,不同香菇多糖分子具有不同的组成和分子量,其分子内化学键的连接方式亦有差异。香菇多糖具有抗肿瘤、抗氧化、提高免疫力、抗辐射和抗副作用等多种生物活性,而其活性受多种因素影响。介绍了香菇多糖热水浸提法和多种辅助提取方法以及对其纯化的方法,列出了香菇多糖不同初级结构形式并探讨了其多种生物活性作用及机制,总结了影响香菇多糖结构和活性的因素,提出了香菇多糖未来研究的趋势。Lentinan,isolated from the fruiting bodies of Lentinula edodes,was usually extracted with hot water.Lentinan has different composition and Mw according to different samples,and their linkage structure of intramolecular chemical bonds are also different.Lentinan has many biological activities including antitumor,anti-oxidation,immunity enhancement,anti-radiation and anti-side effects and so on,and which could be affected by several factors such as molecular weight,glycosidic bond,higher structure,endogenous metal ions,temperature,ultrasonic treatment,organic reagents and alkali liquor,etc.This review introduces hot water extraction of lentinan and several assistant extraction methods in relation to enzyme,ultrasonic,microwave,high pressure and combination of different methods,and also compares their advantages and disadvantages.Then,the separation and purification of lentinan were also introduced.In this review,the monosaccharide composition of lentinan was explained,various possible primary structures of lentinan were summarized and listed,the triple helix structure and its verification method of lentinan were analysed,and the biological activities of lentinan and their mechanisms were discussed.Next,the internal and external factors affecting the structure and activity of lentinan were summarized.In the end,the future research trend was pointed out about lentinan study.

关 键 词：香菇多糖 结构 生物活性 

分 类 号：TS201.2[轻工技术与工程—食品科学]