血浆置换+双重血浆分子吸附系统联合夜间营养干预在老年肝衰竭病人中的疗效观察  

Effect of plasma exchange plus double plasma molecular adsorption system combined with night nutrition intervention in elderly patients with liver failure

作　　者：朱正云[1] 杨柳青 张婷婷[1] 刘丹凤[1] 张岚[1] 许凤琴[2] ZHU Zheng-yun;YANG Liu-qing;ZHANG Ting-ting;LIU Dan-feng;ZHANG Lan;XU Feng-qin(Department of Infection;Nursing Department,the First People’s Hospital of Lianyungang,Lianyungang 222000,China)

机构地区：[1]连云港市第一人民医院感染性疾病科,江苏省连云港市222000 [2]连云港市第一人民医院护理部,江苏省连云港市222000

出　　处：《实用老年医学》2022年第11期1112-1115,共4页Practical Geriatrics

基　　金：江苏省博士后基金资助项目(1701010C)。

摘　　要：目的探讨血浆置换(PE)+双重血浆分子吸附系统(DPMAS)联合夜间营养干预在老年肝衰竭病人中的作用。方法选择2019年6月至2021年12月连云港市第一人民医院收治的72例老年肝衰竭病人为研究对象,按随机数表法分为对照组36例,观察组36例。对照组病人在常规内科综合治疗基础上采用PE+DPMAS治疗,观察组在对照组基础上联合夜间营养干预。观察病人的肝脏储备功能分级(Child-Pugh)评分、营养风险筛查(NRS-2002)评分、血液营养指标,并进行比较分析。结果与干预前相比,2组干预后1周或1个月时Child-Pugh评分、NRS-2002评分、血清白蛋白、前清蛋白、转铁蛋白水平均有改善(P<0.05),2组间上述指标则在干预后1个月时差异有统计学意义(P<0.05)。结论PE+DPMAS联合夜间营养干预对老年肝衰竭病人的治疗效果明显,可以降低营养不良风险,改善病人的肝脏储备功能。Objective To investigate the effect of plasma exchange(PE)+double plasma molecular adsorption system(DPMAS)combined with night nutrition intervention in the elderly patients with liver failure.Methods A total of 72 elderly patients with liver failure treated in the First People’s Hospital of Lianyungang from June 2019 to December 2021 were selected as the research objects.They were divided into control group(n=36)and observation group(n=36)randomly.The patients in the control group were treated with PE+DPMAS on the basis of routine comprehensive medical treatment,and the observation group received night nutrition intervention additionally on the basis of the control group.The Child Pugh score,nutritional risk screening(NRS-2002)score and blood nutritional indexes were observed and compared between the two groups.Results The Child Pugh score,NRS-2002 score,serum levels of albumin,prealbumin and transferrin in the two groups were significantly improved 1 week and 1 month after intervention(P<0.05),and there were significant differences between the two groups 1 month after the intervention(P<0.05).Conclusions PE+DPMAS combined with night nutrition intervention has obvious therapeutic effect on the elderly patients with liver failure,which can reduce the risk of malnutrition and improve the liver reserve function of the patients.

关 键 词：老年人 肝衰竭 血浆置换 双重血浆分子吸附系统 营养 

分 类 号：R575.3[医药卫生—消化系统]