Rhizoma paridis saponins protected against liver injury in diethylnitrosamine-induced mice  

作　　者：Chen Luo Jing-Wen Yao Shu-Li Man Wen-Yuan Gao 

机构地区：[1]Key Laboratory of Industrial Microbiology,Ministry of Education/Tianjin Key Laboratory of Industry Microbiology/National and Local United Engineering Lab of Metabolic Control Fermentation Technology/College of Biotechnology,Tianjin University of Science&Technology,Tianjin 300457,China [2]Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China

出　　处：《Traditional Medicine Research》2023年第2期7-12,共6页TMR传统医学研究

摘　　要：Background:Diethylnitrosamine,one of food additives,possessed a strong carcinogenic effect in human.Rhizoma paridis saponins,as the main active components of Paris polyphylla,have a good anti-cancer effect in our previous research.To verify their inhibitory effect on diethylnitrosamine-induced liver cancer,we carried out this study.Methods:We established diethylnitrosamine-induced mouse hepatocarcinoma models to evaluate antitumor of Rhizoma paridis saponins.Subsequently,gas chromatography-mass spectrometry was applied to analyze the metabolites in the urine and serum samples.Results:Rhizoma paridis saponins alleviated diethylnitrosamine-induced hepatocarcinogenesis.On the one hand,Rhizoma paridis saponins down-regulated the levels of liver function markers,such as alanine aminotransferase,aspartate transaminase and alpha fetoprotein.On the other hand,Rhizoma paridis saponins reduced metabolic disorders by increasing fructose and mannose metabolism,and decreasing pentose and glucuronate interconversion,inositol phosphate metabolism,and the process of saturated fatty acids transforming to unsaturated fatty acids,which based on the regulating mRNA expression of glucose transporter type 4,lactate dehydrogenase A,fatty acid synthetas,acetyl-CoA carboxylase and apolipoprotein A-I.Conclusion:Rhizoma paridis saponins has the potential application to inhibit chemical-induced hepatocarcinogenesis in the future.

关 键 词：Rhizoma paridis saponins liver injury DIETHYLNITROSAMINE METABOLITES 

分 类 号：R285.5[医药卫生—中药学]