血清白细胞介素17和基质金属蛋白酶9表达与非小细胞肺癌患者病理特征的相关性研究  

Study on correlation between the expression of serum interleukin-17 and matrix metalloproteinase-9 and the pathological features of patients with non-small cell lung cancer

作　　者：李静龙 鲍红光[1] 代云峰[2] 陈绍森[1] 赵恩亮 刘云龙[1] 董孝成[1] LI Jinglong;BAO Hongguang;DAI Yunfeng;CHEN Shaosen;ZHAO Enliang;LIU Yunlong;DONG Xiaocheng(Department of Thoracic Surgery,the Second Affiliated Hospital of Qiqihar Medical University,Heilongjiang,Qiqihar 161000,China;Department of Laboratory,the Second Affiliated Hospital of Qiqihar Medical University,Heilongjiang,Qiqihar 161000,China)

机构地区：[1]齐齐哈尔医学院附属第二医院胸外科,黑龙江齐齐哈尔161000 [2]齐齐哈尔医学院附属第二医院检验科,黑龙江齐齐哈尔161000

出　　处：《中国医药科学》2022年第21期172-175,192,共5页China Medicine And Pharmacy

基　　金：黑龙江省省属高等学校基本科研业务费科研项目(2019-KYYWF-1211)。

摘　　要：目的探讨血清白细胞介素17(IL-17)及基质金属蛋白酶9(MMP-9)表达与非小细胞肺癌(NSCLC)患者病理特征的相关性。方法选择2019年2月至2021年12月于齐齐哈尔医学院附属第二医院胸外科确诊的NSCLC患者105例为NSCLC组,选择同期年龄、性别构成与NSCLC组相匹配的气管肺部良性疾病患者201例为对照组,收集两组一般临床资料,比较两组血清IL-17、MMP-9水平差异。结果NSCLC组血清IL-17及MMP-9水平明显高于对照组,差异有统计学意义(P<0.05)。在NSCLC患者中,男性血清IL-17及MMP-9水平与女性比较,差异无统计学意义(P>0.05);年龄≥60岁患者血清IL-17及MMP-9水平与年龄<60岁患者比较,差异无统计学意义(P>0.05);肿瘤直径≥5 cm患者血清IL-17及MMP-9水平与肿瘤直径<5 cm患者比较,差异无统计学意义(P>0.05);腺癌患者血清IL-17及MMP-9水平与鳞癌患者比较,差异无统计学意义(P>0.05)。淋巴转移患者IL-17及MMP-9水平明显高于无淋巴转移患者,TNMⅢ~Ⅳ期患者IL-17及MMP-9水平明显高于TNMⅠ~Ⅱ期患者,差异有统计学意义(P<0.05)。Spearman等级相关分析显示,血清IL-17及MMP-9水平与NSCLC患者淋巴转移明显有关(r=0.646,r=0.448,P<0.05),且血清IL-17及MMP-9水平与NSCLC患者TNM分期呈正相关(r=0.473,r=0.538,P<0.05)。结论IL-17和MMP-9的高表达对NSCLC的转移、病理分期起着重要作用,IL-17和MMP-9的高表达与NSCLC的不良预后有关。Objective To explore the correlation between the expression of serum interleukin-17(IL-17)and matrix metalloproteinase-9(MMP-9)and the pathological features of patients with non-small cell lung cancer(NSCLC).Methods A total of 105 patients diagnosed with NSCLC in the Department of Thoracic Surgery of the Second Affiliated Hospital of Qiqihar Medical University from February 2019 to December 2021 were selected as the NSCLC group,and 201 patients with benign diseases of trachea and lung admitted to our department during the same period,whose age and gender composition were matched with those of the NSCLC group,were selected as the control group.The general clinical data of the two groups were collected and the differences in serum IL-17 and MMP-9 levels between the two groups were compared.Results The serum IL-17 and MMP-9 levels in the NSCLC group were significantly higher than those in the control group,with statistically significant differences(P<0.05).There were no significant differences in serum IL-17 and MMP-9 levels between male and female patients with NSCLC(P>0.05).There were no significant differences in serum IL-17 and MMP-9 levels in patients≥60 years old and patients<60 years old(P>0.05).There were no significant differences in serum IL-17 and MMP-9 levels in patients with tumor diameter≥5 cm and patients with tumor diameter<5 cm(P>0.05).There were no significant differences in serum IL-17 and MMP-9 levels in patients with adenocarcinoma and patients with squamous carcinoma(P>0.05).The IL-17 and MMP-9 levels in patients with lymphatic metastasis were significantly higher than those in patients without lymphatic metastasis,and the IL-17 and MMP-9 levels in patients with TNM stagesⅢ-Ⅳwere significantly higher than those in patients with TNM stages I-II,with statistically significant differences(P<0.05).In the analysis of Spearman correlation coefficient for ranked data,the serum IL-17 and MMP-9 levels were significantly associated with lymphatic metastasis in NSCLC patients(r=0.646,r=0.448,P<0.0

关 键 词：白细胞介素17 基质金属蛋白酶9 非小细胞肺癌 细胞因子 

分 类 号：R734.2[医药卫生—肿瘤]