Targeting the biological activity and biosynthesis of hyperforin:amini-review  

作　　者：LIU Shuqin YU Beilei DAI Jungui CHEN Ridao 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Chinese Journal of Natural Medicines》2022年第10期721-728,共8页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82073970);the National Key Research and Development Program of China(No.2020YFA0908000).

摘　　要：Hyperforin is a representative polycyclic polyprenylated acylphloroglucinols(PPAPs)that exerts a variety of pharmacological activities.The complete biosynthesis pathway of hyperforin has not been elucidated due to its complex structure and unclear genetic background of its source plants.This mini-review focuses on the bioactivity and biosynthesis of hyperforin.These analyses can provide useful insights into the biosynthesis investigations of hyperforin and other PPAPs with complex structures.

关 键 词：HYPERFORIN PPAPs Bioactivity BIOSYNTHESIS PRENYLTRANSFERASE 

分 类 号：R284[医药卫生—中药学] R96[医药卫生—中医学]