HYPERFORIN

作品数：11被引量：10H指数：2
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相关领域：医药卫生更多>>
相关作者：和付林张建成更多>>
相关机构：北京大学中国科学院上海生命科学研究院华中科技大学同济医学院附属协和医院更多>>
相关期刊：《Journal of Cancer Metastasis and Treatment》《Neural Regeneration Research》《Journal of Chinese Pharmaceutical Sciences》《Molecular Plant》更多>>
相关基金：国家自然科学基金更多>>
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Single-cell RNA sequencing facilitates the elucidation of the complete biosynthesis of the antidepressant hyperforin in St. John's wort
《Molecular Plant》2024年第9期1439-1457,共19页Song Wu Ana Luisa Malaco Morotti Jun Yang Ertao Wang Evangelos C.Tatsis 
supported by the National Natural Science Foundation of China,Research Fund for International Excellent Young Scientists(RFIS-Il)(grant 32150610477,awarded to E.C.T.);Strategic Priority Research Program of the Chinese Academy of Sciences(grant XDB27020204,awarded to E.C.T.);Chinese Academy of Sciences,International Partnership Program of CAS(grant 153D31 KYSB20160074,awarded to E.C.T.);National Key Laboratory of Plant Molecular Genetics Special Fund.
Hyperforin is the compound responsible for the effectiveness of St.John's wort(Hypericum perforatum)as an antidepressant,but its complete biosynthetic pathway remains unknown.Gene discovery based on co-expression anal...
关键词：HYPERFORIN Hypericum perforatum de novo genome sequencing single-cell RNA sequencing biosyn-thetic pathway MEROTERPENOIDS 
Targeting the biological activity and biosynthesis of hyperforin:amini-review
《Chinese Journal of Natural Medicines》2022年第10期721-728,共8页LIU Shuqin YU Beilei DAI Jungui CHEN Ridao 
supported by the National Natural Science Foundation of China(No.82073970);the National Key Research and Development Program of China(No.2020YFA0908000).
Hyperforin is a representative polycyclic polyprenylated acylphloroglucinols(PPAPs)that exerts a variety of pharmacological activities.The complete biosynthesis pathway of hyperforin has not been elucidated due to its...
关键词：HYPERFORIN PPAPs Bioactivity BIOSYNTHESIS PRENYLTRANSFERASE 
The group of Professor Houhua Li have made progress in the total synthesis of Hyperforin,a medicinal ingredient of Hypericum perforatum
《Journal of Chinese Pharmaceutical Sciences》2022年第3期233-234,共2页黎后华 
2022年2月7日,北京大学药学院天然药物及仿生药物国家重点实验室黎后华研究员团队在国际著名期刊《Angewandte Chemie International Edition》上在线发表最新研究成果:“Enantioselective Total Synthesis of Hyperforin and Pyrohyper...
关键词：北京大学药学院 药效成分 贯叶连翘 化学合成 最新研究成果 团队 
The antiangiogenic phloroglucinol hyperforin inhibits the secretion of proMMP-2, proMMP-9 and VEGF-A during apoptosis of primary acute myeloid leukemia cells
《Journal of Cancer Metastasis and Treatment》2021年第1期588-603,共16页Faten Merhi Ruoping Tang Ollivier Legrand Florence Nguyen-Khac Santos A.Susin Brigitte Bauvois 
supported by the French National Institute of Health and Medical Research(INSERM).This research received no external funding.
Aim:Angiogenesis is observed in acute myeloid leukemia(AML).AML cells abnormally proliferate and are resistant to death.Positive regulators of angiogenesis,VEGF-A and matrix metalloproteinases(MMPs)2 and 9 are markers...
关键词：Acute myeloid leukemia APOPTOSIS HYPERFORIN matrix metalloproteinase VEGF SECRETION 
Super Antibiotics, Part VI: Hyperforin, Revision of Stereochemistry. Short Communications
《International Journal of Analytical Mass Spectrometry and Chromatography》2018年第2期37-39,共3页Ilia Brondz 
This short communication is an overview and revision of previous published papers about the relative and absolute stereochemistry of hyperforin and discovery of a new isomer of hyperforin that has been named perforatrin.
关键词：REVISION Relative and Absolute STEREOCHEMISTRY HYPERFORIN Perforatrin 
Super Antibiotics, Part IV. Hyperforin, Relative and Absolute Stereochemistry Elucidated by Gas-Chromatography Mass-Spectrometry with Supersonic Molecular Beams
《International Journal of Analytical Mass Spectrometry and Chromatography》2017年第3期70-85,共16页Ilia Brondz 
Relative and absolute stereochemistry for hyperforin has been proposed by Brondz et al. was supported and new isomer of hyperforin-perforatrin has been discovered. Relative and absolute stereochemistry for perforatrin...
关键词：HYPERFORIN Perforatrin RELATIVE and Absolute STEREOCHEMISTRY Gas Chromatography-Mass SPECTROMETRY CHIRALITY 
Super Antibiotics, Part II. Hyperforin, Mass Spectroscopy (MS) and Gas Chromatography-Mass Spectrometry (GC-MS), Evidence of Permeability of the Blood-Testis Barrier (BTB) and the Blood-Brain Barrier (BBB) to Hyperforin被引量：2
《International Journal of Analytical Mass Spectrometry and Chromatography》2016年第4期66-73,共8页Ilia Brondz 
In the first article of this series, we presented some evidence of hyperforin as an antibiotic, antiprotozoal, antiviral, anticancer, and immunomodulatory substance. In the present article, evidence of the permeabilit...
关键词：ANTIBIOTICS HYPERFORIN Super antibiotic Mass Spectroscopy Gas Chromatography-Mass Spectrometry Blood-Testis Barrier Blood-Brain Barrier Methicillin-Resistant Staphylococcus aureus (MRSA) 
Recent enhancement of the immunity in AIDS and other immunocompromised patients by hyperforin an antibiotic from <i>Hypericum perforatum</i>L. (<i>in vitro</i>model) part I
《Journal of Biophysical Chemistry》2012年第4期304-310,共7页Ilia Brondz Anton Brondz 
Today, Hypericum perforatum L. is probably one of the best-characterized medicinal plants, and hyperforin is its best-characterized constituent. Extracts from H. perforatum are widely used as antidepressants;however, ...
关键词：IMMUNOMODULATION PHAGOCYTOSIS AIDS E. coli HYPERFORIN HYPERICUM perforatum L. 
Effect of borneol and electroacupuncture on the distribution of hyperforin in the rat brain被引量：6
《Neural Regeneration Research》2011年第24期1876-1882,共7页Bin Yu Ming Ruan Yong Sun Xiaobing Cui Yun Yu Lingling Wang Taihui Fang 
the National Natural Science Foundation of China,No: 81001651;Opening Project from Key Laboratory of Integrative Acupuncture and Drugs Constructed by Jiangsu Provincial and Chinese Education Ministry,No: KJA200905
Hyperforin is an antidepressant drug that has unstable therapeutic effects, due to its poor ability to cross the blood-brain barrier. Borneol and electroacupuncture have both been found to increase the permeability of...
关键词：HYPERFORIN BORNEOL ELECTROACUPUNCTURE blood-brain barrier brain targeting neural regeneration 
Pseudohypericin and Hyperforin in Hypericum perforatum from Northern Turkey:Variation among Populations,Plant Parts and Phenological Stages
《Journal of Integrative Plant Biology》2008年第5期575-580,共6页Cüneyt irak Jolita Radusiene Valdimaras Janulis Liudas Ivanauskas 
Hypericum perforatum is a perennial medicinal plant known as ＂St. John＇s wort＂ in Western Europe and has been used in the treatment of several diseases for centuries. In the present study, morphologic, phenologic a...
关键词：HYPERFORIN Hypericum perforatum morphologic and phenologic variations population variability pseudohypericin. 
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