HYPERICUM

作品数：57被引量：72H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：胡正海沈宗根李景原吕洪飞吴楠更多>>
相关机构：甘肃林业职业技术学院华中科技大学吉林农业科技学院西北大学更多>>
相关期刊：《Science Bulletin》《Journal of Food Science and Engineering》《Chinese Herbal Medicines》《长江大学学报（自然科学版）》更多>>
相关基金：国家自然科学基金中国博士后科学基金教育部留学回国人员科研启动基金国家重点基础研究发展计划更多>>
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Hymoins A–C,three unusual polycyclic polyprenylated acylphloroglucinols with lipid-lowering activity from Hypericum monogynum
《Chinese Chemical Letters》2025年第3期411-414,共4页Chunmao Yuan Yanrong Zeng Lei Huang Yu Mou Jun Jin Ping Yi Yanmei Li Xiaojiang Hao 
financially supported by the National Natural Science Foundation of China(Nos.32270413,82060631,82160808,and 82360035);the Science and Technology Department of Guizhou Province(Nos.QKHJC 2020–1Z076,QKHJC-ZK[2023]YB156,QKHJC-ZK[2021]YB569,and QKHPTRC[2020]5008);Excellent Young Talents Plan of Guizhou Medical University(2023,No.106);the 13thbatch of outstanding young scientific and technological talents in Guizhou Province(No.QKHPTRC[2021]5633);Guizhou Science and Technology Innovation Talent Team(No.QKHPTRC–CXTD[2022]007);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);the project of State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(Nos.FAMP202102K and QJJ[2023]113)。
Hymoins A–C(1–3),three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs)were isolated from the flowers of Hypericum monogynum.Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP.Hymoin...
关键词：Hypericum monogynum Polycyclic polyprenylated ACYLPHLOROGLUCINOLS Structure elucidation Lipid-lowering activity Mechanistic study 
Hyperkouytones A—O,New Polyprenylated Acylphloroglucinols from Hypericum kouytchense with Multidrug Resistance Reversal Activity
《Chinese Journal of Chemistry》2024年第24期3293-3307,共15页Hua-Yong Lou Mei-Jun Chen Ping Yi Jun Jin Yan-Rong Zeng Wei Gu Zhan-Xing Hu Jue Yang Xiao-Jiang Hao Chun-Mao Yuan 
supported by the National Natural Science Foundation of China(Nos.32270413,82060631,and 82304348);the Science and Technology Department of Guizhou Province(No.QKHJC-ZK[2023]YB156);Excellent Young Talents Plan of Guizhou Medical University(2023,No.106);the 13th batch of outstanding young scientific and technological talents in Guizhou Province(No.QKHPTRC[2021]5633);Guizhou Science and Technology Innovation Talent Team(No.QKHPTRCCXTD[2022j007);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);Guiyang Science and Technology Talent Training Project([2023]48-5);the project of State Key Laboratory of Functions and Applications of Medicinal Plants,GuizhouMedical University(No.QJJ[2023]113);Guizhou Provincial Engineering Research CenterforNatural Drugs.
Given the lack of systematic polyprenylated acylphloroglucinols(PPAPs)research on traditional Chinese medicine of Hypericum kouytchense,this plant was applied for the phytochemical study,which led to fifteen new PPAP...
关键词：Natural products Hypericum kouytchense PHYTOCHEMISTRY Structure elucidation Multidrug resistance reversal activity 
Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri
《Chinese Journal of Chemistry》2024年第18期2180-2186,共7页Jin-Qiu You Yun-Qi Jin Meng-Yu Li Bo-Chao Zhang Xin-Yu Sun Chun-Yong Ding Jing-Ya Li Ai-Jun Hou 
supports from the National Natural Science Foundation of China(Grant No.22277074);Zhiyuan Future Scholar Program(Grant No.ZIRC2022-14)of Zhiyuan College,Shanghai Jiao Tong University are gratefully acknowledged.
Hyperlanins A(1)and B(2),two highly rearranged polycyclic polyprenylated acylphloroglucinol(PPAP)-related meroterpenoids based on different new carbon skeletons,were isolated from Hypericum lancasteri.Compound 1 incor...
关键词：Natural products Hypericum lancasteri MEROTERPENOIDS STRUCTUREELUCIDATION INFLAMMATION 
Spirohypertones A and B as potent antipsoriatics:Tumor necrosis factor-αinhibitors with unprecedented chemical architectures
《Acta Pharmaceutica Sinica B》2024年第6期2646-2656,共11页Yulin Duan Weiguang Sun Yongqi Li Zhengyi Shi Lanqin Li Yeting Zhang Kun Huang Zhiping Zhang Changxing Qi Yonghui Zhang 
supported by the Program for Changjiang Scholars of Ministry of Education of the People's Republic of China(T2016088);the National Natural Science Foundation for Distinguished Young Scholars(81725021,China)the National Natural Science Foundation of China(Nos.82003633,32100321 and 32300335);the National Natural Science Foundation of Hubei Province(2023AFB791 and 2023AFB530,China);Knowledge Innovation Project of Wuhan Science and Technology Bureau(2023020201020534,China);the Research and Development Program of Hubei Province(2020BCA058,China);the Open Foundation of Hubei Key Laboratory of Wudang Local Chinese Medicine Research(WDCM2023010,China);Funded by Open Research Fund Program of State Key Laboratory of Biocatalysis and Enzyme Engineering(SKLBEE2023003,China).
Tumor necrosis factor-α(TNF-α)is a promising target for inflammatory and autoimmune diseases.Spirohypertones A(1)and B(2),two unprecedented polycyclic polyprenylated acylphloroglucinols with highly rearranged skelet...
关键词：Hypericum patulum Polycyclic polyprenylated acylphloroglucinols Tumor necrosis factor-αinhibitory activity PSORIASIS 
Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum
《Chinese Journal of Natural Medicines》2024年第3期273-279,共7页DUAN Yulin SHI Zhengyi SONG Fei HOU Zhangrong TAN Xiaosheng ZHANG Yeting HAO Xincai CHEN Gang QI Changxing ZHANG Yonghui 
supported by the Program for Changjiang Scholars of Ministry of Education of the People’s Republic of China(No.T2016088);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Science and Technology Project of China(No.2018ZX09201001-001-003);the National Natural Science Foundation of China(Nos.82003633,32100321,and 32300335);the Research and Development Program of Hubei Province(No.2020BCA058);the Open Foundation of Hubei Key Laboratory of Wudang Local Chinese Medicine Research(No.WDCM2022003);the National Natural Science Foundation of Hubei Province(No.2023AFB530);the Knowledge Innovation Project of Wuhan Science and Technology Bureau(No.2023020201020534).
Hyparillums A(1)and B(2),two previously unidentified polycyclic polyprenylated acylphloroglucinols(PPAPs)with intricate architectures,were isolated from Hypericum patulum Thunb.Hyparillum A was the first PPAP with eig...
关键词：Polycyclic polyprenylated acylphloroglucinols Hypericum patulum Thunb. Immunosuppressive activities Structure elucidation. 
The parallel biosynthesis routes of hyperoside from naringenin in Hypericum monogynum被引量：1
《Horticulture Research》2023年第9期247-259,共13页Yingying Wang Zhirong Cui Qianqian Li Shuai Zhang Yongyi Li Xueyan Li Lingyi Kong Jun Luo 
supported by the National Natural Science Foundation of China(No.32070389);the‘Double First-Class’University project of China Pharmaceutical University(CPU2022QZ29).
Hyperoside is a bioactive flavonoid galactoside in both medicinal and edible plants.It plays an important physiological role in the growth of flower buds.However,the hyperoside biosynthesis pathway has not been system...
关键词：INTERIOR concerning HYPER 
Bioassay-guided isolation of α-Glucosidase inhibitory constituents from Hypericum sampsonii
《Chinese Journal of Natural Medicines》2023年第6期443-453,共11页TAO Linlan XU Shuangyu ZHANG Zizhen LI Yanan YANG Jue GU Wei YI Ping HAO Xiaojiang YUAN Chunmao 
supported by the National Natural Science Foundation of China(No.32270413,U1812403);the Science and Technology Department of Guizhou Province(No.QKH 2020-1Z076);the 13th batch of Outstanding Young Scientific and Technological Talents in Guizhou Province(No.QKHPTRC[2021]5633);Cultivation project of National Natural Science Foundation of Guizhou Medical University(No.19NSP003);the Education Department of Guizhou Province(No.QJH KY[2021]189);the Natural Science Foundation of Guizhou Province(No.QKHZYD[2022]4015);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);“Light of the West”Talent Cultivation Program of Chinese Academy of Sciences for Chunmao Yuan(No.RZ[2020]82).
This study employed the α-glucosidase inhibitory activity model as an anti-diabetic assay and implemented a bioactivity-guided isolation strategy to identify novel natural compounds with potential therapeutic propert...
关键词：Hypericum sampsonii Chemical constituents Structure elucidation Α-GLUCOSIDASE Molecular docking 
New secondary metabolites with cytotoxicity from fungus Penicillium roqueforti
《Natural Products and Bioprospecting》2023年第1期577-584,共8页Shuyuan Mo Ziming Zhao Zi Ye Zhihong Huang Yaxin Zhang Wanqi Yang Jianping Wang Zhengxi Hu Yonghui Zhang 
the National Program for Support of Top-notch Young Professionals(No.0106514050);the National Natural Science Foundation of China(Nos.82273811 and 31870326);the National Key R&D Program of China(No.2021YFA0910500);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Research and Development Program of Hubei Province(No.2020BCA058);the Chinese Medicine Research Foundation of Health Commission of Hubei Province(No.ZY2021Z019).
Two novel compounds including a cyclohelminthol type polyketide(namely oxaleimide K,1)and a maleimide deriva-tive(namely peniroquefortine A,2),and a new natural product(namely 2-(acetylamino)-N-[(1E)-2-phenylethenyl]-...
关键词：Hypericum beanii N.Robson Root soil-derived fungus Penicillium roqueforti Structural elucidation CYTOTOXICITY 
遍地金Hypericum wightianum中2对间苯三酚类对映异构体及其绝对构型被引量：1
《中国中药杂志》2023年第2期421-429,共9页张瑞飞 范彦晓 纪圆圆 龙春林 
国家自然科学基金项目(31870316,31761143001);生态环境部生物多样性调查评估项目(2019HJ2096001006)。
通过柱色谱法对金丝桃科药用植物遍地金Hypericum wightianum全草乙醇提取物中的化学成分进行分离纯化,采用核磁共振、高分辨质谱、圆二色谱等波谱学方法鉴定了22个化合物,包括8个异戊烯基间苯三酚类(1~8)、3个色酮类(9~11)和3个萜类(14...
关键词：金丝桃属 遍地金 化学成分 间苯三酚 
Elodexanthones A—J, Isoprenylated Xanthone Derivatives with Diverse Skeletons and Bioactivities from Hypericum elodeoides被引量：1
《Chinese Journal of Chemistry》2022年第24期2939-2946,共8页Yanbing Mu Yaqi Li Qiji Li Wenjun Xu Yunpeng Sun Siyuan Wang Letian Cui Lingyi Kong Jun Luo 
supported by the National Natural Science Foundation of China(32170406);the“Double First-Class”University project(CPU2018GY08).
Elodexanthones A—J (1—10), two pairs of rearranged isoprenylated xanthone enantiomers with an unprecedent 6/6/5/6 tetracyclic core (1—2) along with seven new isoprenylated xanthones (3—9) and a pair of phenylpropa...
关键词：Hypericum eldeoides Isoprenylated xanthones Structure elucidation Biological activity INFLAMMATORY 
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