Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri  

作　　者：Jin-Qiu You Yun-Qi Jin Meng-Yu Li Bo-Chao Zhang Xin-Yu Sun Chun-Yong Ding Jing-Ya Li Ai-Jun Hou 

机构地区：[1]Shanghai Frontiers Science Center of Drug Target Identification and Delivery,School of Pharmaceutical Sciences,Shanghai Jiao Tong University,Shanghai200240,China [2]National Key Laboratory of Innovative Immunotherapy,Shanghai Jiao Tong University,Shanghai 200240,China [3]Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [4]Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

出　　处：《Chinese Journal of Chemistry》2024年第18期2180-2186,共7页中国化学（英文版）

基　　金：supports from the National Natural Science Foundation of China(Grant No.22277074);Zhiyuan Future Scholar Program(Grant No.ZIRC2022-14)of Zhiyuan College,Shanghai Jiao Tong University are gratefully acknowledged.

摘　　要：Hyperlanins A(1)and B(2),two highly rearranged polycyclic polyprenylated acylphloroglucinol(PPAP)-related meroterpenoids based on different new carbon skeletons,were isolated from Hypericum lancasteri.Compound 1 incorporates an unprecedented 5/6/7/5 ring system featuring a 3,13-dioxatetracyclo[9.2.1.12.5.01.8]pentadecane core.Compound 2 possesses a unique compact 6/6/5/6/6/5/6 ring system with a caged tetracyclo[6.2.1.13.8.05,11]dodecane motif.Their structures were established by spectroscopic data,X-ray diffraction,and computational approaches.Both compounds showed anti-inflammatory activity in vitro.Compounds 1 and 2 could decrease the lipopolysaccharide(LPS)-/nigericin-induced IL-1βrelease in THP-1 cells.Both compounds also showed inhibition in hypoxia-inducible factor-1α(HIF-1αa)pathway luciferase reporter assay.

关 键 词：Natural products Hypericum lancasteri MEROTERPENOIDS STRUCTUREELUCIDATION INFLAMMATION 

分 类 号：O62[理学—有机化学]