Clinical features and prognosis of multiple myeloma and orbital extramedullary disease:Seven cases report and review of literature  

作　　者：Wan-Li Hu Jia-Yin Song Xin Li Xiao-Jiao Pei Jia-Jia Zhang Man Shen Ran Tang Zhen-Yu Pan Zhong-Xia Huang 

机构地区：[1]Department of Hematology,Multiple Myeloma Medical Center of Beijing,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100043,China [2]Department of Radiology,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100043,China

出　　处：《World Journal of Clinical Cases》2022年第33期12365-12374,共10页世界临床病例杂志

基　　金：Supported by Science and Technology Project of Beijing Science and Technology Commission,No.Z171100000417010;Construction Project on Key Medical Disciplines of Shijingshan District Health Committee of Beijing Municipality.

摘　　要：BACKGROUND Multiple myeloma(MM)complicated with extramedullary disease(EMD)has a poor prognosis and is a limiting factor in the treatment of MM,and no standard treatment is recommended in international guidelines.Few studies have reported MM with periorbital EMD.CASE SUMMARY In this paper,the clinical characteristics and survival of seven patients with multiple myeloma and orbital are described and analyzed.The common ocular symptoms were blurred vision,proptosis and/or eye movement disorders,IgG type MM may be a risk factor for orbital involvement.Of them,six patients were treated with bortezomib-based regimens.The median overall survival(OS)and progression free survival for the entire cohort were 48 and 33 mo,respectively,which was much worse than the OS reported for MM patients without orbital EMD.CONCLUSION Orbital MM may have significantly shortened survival for the entire cohort,so multidisciplinary collaboration is emphasized and recommended in the diagnosis and treatment of these difficult cases.

关 键 词：Multiple myeloma Extramedullary disease PERIORBITAL Treatment SURVIVAL Case report 

分 类 号：R733.3[医药卫生—肿瘤]