Multiple myeloma presenting with amyloid arthropathy as the first manifestation:Two case reports  

作　　者：Chuan He Xue-Ping Ge Xiao-Hui Zhang Ping Chen Bing-Zong Li 

机构地区：[1]Department of Haematology,The Second Affiliated Hospital of Soochow University,Suzhou 215004,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2022年第35期13028-13037,共10页世界临床病例杂志

摘　　要：BACKGROUND Multiple myeloma(MM)can be accompanied by amyloidosis,which occurs in a small number of patients and is characterized by deposition of light chains in the joints,leading to multiple myeloma-associated amyloid arthropathy(MAA).As a rare complication of MM,clinical manifestations of MAA are often similar to those of rheumatoid arthritis,and the two are easily confused.CASE SUMMARY In recent years,our center treated two patients of MM with amyloid arthropathy as the first manifestation,both of whom presented with polyarthritis.After treatment for MM,both patients achieved complete remission.However,subsequently,the two patients underwent hip arthroplasty for femoral neck fractures.Congo red staining and immunofluorescence of the joint tissues confirmed MAA after surgery.Eventually,one of the patients died of MM recurrence,while the other survived.CONCLUSION MAA should be regarded as an initial symptom of MM and should be taken seriously.

关 键 词：AMYLOIDOSIS POLYARTHRITIS Monoclonal gammopathies Immunoglobulin light chain amyloidosis Multiple myeloma Case report 

分 类 号：R733.3[医药卫生—肿瘤]