Rifabutin as salvage therapy for Helicobacter pylori eradication:Cornerstones and novelties  

作　　者：Antonia Valeria Borraccino Francesca Celiberto Maria Pricci Bruna Girardi Andrea Iannone Maria Rendina Enzo Ierardi Alfredo Di Leo Giuseppe Losurdo 

机构地区：[1]Section of Gastroenterology,Department of Emergency and Organ Transplantation,University of Bari,Bari 70124,Italy [2]THD SpA,Correggio 42015,Italy

出　　处：《World Journal of Gastroenterology》2022年第45期6356-6362,共7页世界胃肠病学杂志（英文版）

摘　　要：When several Helicobacter pylori eradication treatments fail,guidelines recommend a cultured guided approach;however,culture is not widely available.Therefore,a rifabutin based regimen could be the best solution.Rifabutin indeed shows a low rate of antibiotic resistance.Rifabutin is generally used in combination with amoxicillin in a triple therapy,with eradication rates about 80%in third-line regimens.The ideal duration of this therapy should range between 10 and 12 d.Combinations with antibiotics other than amoxicillin have demonstrated even better results,such as vonoprazan,which is a type of novel acid suppressor drug.Finally,a new formulation of triple therapy in a single capsule is under investigation,which is a field that deserves further investigation.Some notes of caution about rifabutin should be mentioned.This drug is used to treat tuberculosis or atypical mycobacteria;therefore,before starting a rifabutin-based eradication regimen,Mycobacterium tuberculosis infection should be thoroughly tested,since its use could promote the development of antibiotic resistance,thus affecting its effectiveness against Koch’s bacillus.Additionally,some serious side effects must be evaluated before starting any rifabutin-based therapy.Adverse effects include fever,nausea,vomiting and bone marrow suppression.For this reason,full blood count surveillance is required.

关 键 词：Helicobacter pylori ERADICATION RIFABUTIN Antibiotic resistance Rescue therapy TREATMENT 

分 类 号：R573[医药卫生—消化系统]