Elevated calprotectin levels are associated with mortality in patients with acute decompensation of liver cirrhosis  

作　　者：Camila Matiollo Elayne Cristina de Morais Rateke Emerita Quintina de Andrade Moura Michelle Andrigueti Fernanda Cristina de Augustinho Tamara Liana Zocche Telma Erotides Silva Lenyta Oliveira Gomes Mareni Rocha Farias Janaina Luz Narciso-Schiavon Leonardo Lucca Schiavon 

机构地区：[1]Clinical Analysis Laboratory Unit,University Hospital,Federal University of Santa Catarina,Florianopolis 88040-900,Brazil [2]Division of Gastroenterology,University Hospital,Federal University of Santa Catarina,Florianópolis 88040-900,Brazil [3]Department of Pharmaceutical Sciences Health Sciences Center,Federal University of Santa Catarina,Florianópolis 88040-370,Brazil [4]Division of Gastroenterology,Department of Internal Medicine,Federal University of Santa Catarina,Florianopolis 88040-900,SC,Brazil

出　　处：《World Journal of Hepatology》2022年第11期1964-1976,共13页世界肝病学杂志（英文版）（电子版）

基　　金：Supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico.

摘　　要：BACKGROUND Acute decompensation(AD)of cirrhosis is related to systemic inflammation and elevated circulating cytokines.In this context,biomarkers of inflammation,such as calprotectin,may be of prognostic value.AIM To evaluate serum calprotectin levels in patients hospitalized for complications of cirrhosis.METHODS This is a prospective cohort study that included 200 subjects hospitalized for complications of cirrhosis,20 outpatients with stable cirrhosis,and 20 healthy controls.Serum calprotectin was measured by enzyme-linked immunosorbant assay.RESULTS Calprotectin levels were higher among groups with cirrhosis when compared to healthy controls.Higher median calprotectin was related to Child-Pugh C,ascites,and hepatic encephalopathy.Higher calprotectin was related to acute-on-chronic liver failure(ACLF)and infection in the bivariate,but not in multivariate analysis.Calprotectin was not associated with survival among patients with ACLF;however,in patients with AD without ACLF,higher calprotectin was associated with a lower 30-d survival,even after adjustment for chronic liver failure-consortium(CLIF-C)AD score.A high-risk group(CLIF-C AD score≥60 and calprotectin≥580 ng/mL)was identified,which had a 30-d survival(27.3%)similar to that of patients with grade 3 ACLF(23.3%).CONCLUSION Serum calprotectin is associated with prognosis in patients with AD without ACLF and may be useful in clinical practice to early identify patients with a very low short-term survival.

关 键 词：INFLAMMATION Liver cirrhosis Acute-on-chronic liver failure 

分 类 号：R575.2[医药卫生—消化系统]