Beneficial Regulatory Effects of Sesamin on Intestinal Flora of Mice  

作　　者：Yu DENG Mengxi WANG Xiaogeng LIU Pan LIU Hong LEI 

机构地区：[1]College of Food Science and Engineering,Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety,Nanjing 210023,China

出　　处：《Agricultural Biotechnology》2022年第6期84-88,共5页农业生物技术（英文版）

基　　金：Support by National Natural Science Foundation of China(Grant No.31872899);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).

摘　　要：The effects of sesamin on intestinal microflora of mice with normal diet were studied by in vitro animal feces anaerobic culture system.The results showed that treatment with sesamin could significantly change the intestinal flora structure of mice,increasing the abundance of probiotics Lactobacillus and Bifidobacterium and inhibiting the growth of harmful bacteria Enterococcus.High-throughput sequencing analysis showed that sesamin could affect the structure and composition of fecal microflora of mice,and the abundance of probiotics such as Bacillus and Bifidobacterium increased.Sesamin also could increase the expression of tight contiguous protein Occludin and Claudin-1 in colonic tissue of mice,which was benefit to the adhesion of probiotics.In conclusion,sesamin intervention could improve the composition and abundance of intestinal microorganisms in mice with normal diet,which had a beneficial regulatory effect on the intestinal health.

关 键 词：SESAMIN Intestinal flora Beneficial regulatory effect Abundance of probiotics 

分 类 号：TS201.4[轻工技术与工程—食品科学]