Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice  

作　　者：Aimei Liao Xing Lyu Jiarui Ma Yinchen Hou Ming Hui Na Liu Yi Zhao Yixiang Cui Jihong Huang 

机构地区：[1]College of Biological Engineering,Henan University of Technology,Luoyang 471000,China [2]Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat,Luoyang 471000,China [3]Zhengzhou Synear Food Co.,Ltd.,Zhengzhou 450000,China [4]School of Food and Pharmacy,Xuchang University,Xuchang 461000,China

出　　处：《Food Science and Human Wellness》2023年第4期1300-1308,共9页食品科学与人类健康（英文）

基　　金：funded by Zhongyuan Scholars in Henan Province(192101510004);Major Science and Technology Projects for Public Welfare of Henan Province(201300110300);Innovation Demonstration Special Project of Henan Province(201111110100);financially supported by Key Project Foundation of Natural Science Research of Universities of Henan Province in China(20A550004);Fundamental Research Funds for the Henan Provincial Colleges and Universities in Henan University of Technology(HAUT)and High-Level Talents Research Fund of HAUT(2018QNJH13,and 2018BS012)。

摘　　要：Wheat embryo globulin(WEG)has been proven to possess multiple biological activities,including antioxidative properties,immunomodulatory,and so on.Aged mouse model were established by subcutaneous injection of D-galactose(D-gal),and the effects of WEG on learning,memory,and antioxidant capacity in aging mice were explored through behavioural tests and antioxidant enzyme activities determination.Compared with the Model group,WEG improved the percentage of the platform quadrant,increased the number of crossing platforms,and enhanced the identification indexs.WEG also increased total antioxidant capacity(T-AOC),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)activities in the liver and brains of aging mice,and reduced malondialdehyde(MDA)content.Pathological observations indicated that WEG protected against damage to brain in D-gal-induced aging mice.These results effectively revealed that WEG not only improved the abilities of learning and memory,and the cognitive impairment,but also delayed the aging process of the D-gal-induced mice.

关 键 词：Wheat embryo globulin Antioxidant activity D-GALACTOSE Superoxide dismutase Glutathione peroxidase 

分 类 号：TS201.2[轻工技术与工程—食品科学]