D-GALACTOSE

作品数：68被引量：225H指数：8
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Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cells
《Food Science and Human Wellness》2025年第3期880-891,共12页Xiaoyu Xia Han Li Xianbing Xu Zhenyu Wang Junjie Yi Guanghua Zhao Ming Du 
financially supported by the National Natural Science Foundation of China(31730069);Graduate Innovation Fund of Dalian Polytechnic University。
Aging is a physiological process that leads to degeneration and functional decline of the brain.This is accompanied by intracellular peroxidation and neuronal apoptosis.Natural antioxidants possess a remarkable effect...
关键词：FERRITIN LYCOPENE NANOCARRIER Neuroprotection Aging 
Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening
《Current Medical Science》2024年第4期748-758,共11页Shan-shan HU Tong-yao WANG Lu NI Fan-xin HU Bo-wen YUE Ying ZHENG Tian-lun WANG Abhishek KUMAR Yan-yan WANG Jin-e WANG Zhi-yong ZHOU 
supported by the Natural Science Foundation of Yichang City of China(No.A23-1-075).
Objective Icariin(ICA)has a good neuroprotective effect and can upregulate neuronal basal autophagy in naturally aging rats.Mitochondrial dysfunction is associated with brain aging-related neurodegenerative diseases.A...
关键词：ICARIIN neuronal injury mitochondrial dysfunction mitochondrial permeability transition pore AUTOPHAGY 
Lactobacillus plantarum AR113 attenuates liver injury in D-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress
《Food Science and Human Wellness》2024年第2期885-897,共13页Yongjun Xia Yujie Gong Xiangna Lin Yijin Yang Xin Song Guangqiang Wang Zhiqiang Xiong Yangyang Qian Zhuan Liao Hui Zhang Lianzhong Ai 
supported by the National Science Fund for Distinguished Young Scholars(32025029);the Shanghai Education Committee Scientific Research Innovation Projects(2101070007800120);the Yili Health Science Foundation of Chinese Institute of Food Science and Technology(2021-Y06);the Shanghai Engineering Research Center of food microbiology program(19DZ2281100)。
Probiotics could effectively eliminate excess reactive oxygen species(ROS)generated during aging or lipid metabolism disorders,but their mechanism is unclear.The major purpose of this study was to investigate the mech...
关键词：Lactiplantibacillus plantarun AR113 HEPG2 D-GALACTOSE Oxidative stress ER stress 
Effect of Ningxin-Yishen Formula on D-galactose-induced Premature Ovarian Insufficiency Mice by Inhibiting p53
《Clinical Complementary Medicine and Pharmacology》2023年第4期1-9,共9页Jiawen Ma Zaiyang Zhang Xin Yan Cenglin Xu Yizhou Zhang 
This work was financially supported by Postgraduate Scientific Re-search Foundation of Zhejiang Chinese Medical University[Number:2020YKJ12].
Background:The prevalence of premature ovarian insufficiency(POI)is gradually increasing,safer and more effective treatments are urgently needed.Objective:The aim of this study was to evaluate the effects of Ningxin-Y...
关键词：Ningxin-Yishen formula Premature ovarian insufficiency D-galactose Network pharmacology P53 Traditional Chinese Medicine 
Jujuboside a Improved Energy Metabolism in Senescent H9c2 Cells Injured by Ischemia, Hypoxia, and Reperfusion through the CD38/Silent Mating Type Information Regulation 2 Homolog 3 Signaling Pathway
《World Journal of Traditional Chinese Medicine》2023年第3期322-329,共8页Yi-Ran Hu Hui-Yan Qu Jia-Ying Guo Tao Yang Hua Zhou 
Construction of atrial fibrillation-specific disease database(shdc2020cr6012-003);3 years action plan of Shanghai Shenkang Medical Development Center(shdc2020cr1053b);Science and technology support project of Shanghai Municipal Commission of Science and Technology(18401932800);Shanghai Shenkang medical development center emerging frontier technology joint research project(shdc12018125)。
Objective:This study explored the myocardial protection role of Jujuboside A through an ischemia–hypoxia–reperfusion(IHR)model.Materials and Methods:H9c2 cells were induced by D-galactose(D-gal)and IHR to establish ...
关键词：CD38 D-GALACTOSE ischemia hypoxia and reperfusion Jujuboside A nicotinamide adenine dinucleotide 
Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice被引量：1
《Food Science and Human Wellness》2023年第4期1300-1308,共9页Aimei Liao Xing Lyu Jiarui Ma Yinchen Hou Ming Hui Na Liu Yi Zhao Yixiang Cui Jihong Huang 
funded by Zhongyuan Scholars in Henan Province(192101510004);Major Science and Technology Projects for Public Welfare of Henan Province(201300110300);Innovation Demonstration Special Project of Henan Province(201111110100);financially supported by Key Project Foundation of Natural Science Research of Universities of Henan Province in China(20A550004);Fundamental Research Funds for the Henan Provincial Colleges and Universities in Henan University of Technology(HAUT)and High-Level Talents Research Fund of HAUT(2018QNJH13,and 2018BS012)。
Wheat embryo globulin(WEG)has been proven to possess multiple biological activities,including antioxidative properties,immunomodulatory,and so on.Aged mouse model were established by subcutaneous injection of D-galact...
关键词：Wheat embryo globulin Antioxidant activity D-GALACTOSE Superoxide dismutase Glutathione peroxidase 
Protective Effect of SGLT2 Inhibitor on D-Galactose-Induced Senescence in Mice and Its Mechanism
《Journal of Biosciences and Medicines》2023年第5期286-302,共17页Zijun Ma Meilin Xu Kaiqin Jin Guangfu Zhu Xin Chen 
Objective: To observe the cerebral protective effect of dagliflozin, a sodium-glucose co-transport protein 2 (SGLT2) inhibitor, in aging mice and to explore its molecular mechanism. Methods: 1. 66 male C57BL/6 mice we...
关键词：Aging Neurodegenerative Diseases SGLT2 Inhibitors Oxidative Stress SIRT1 Signalling Pathway 
Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice被引量：5
《Acta Pharmacologica Sinica》2023年第4期741-751,共11页Chen Hong Zhi Wang Si-li Zheng Wen-jun Hu Shu-na Wang Yan Zhao Chao-yu Miao 
supported by grants from the National Natural Science Foundation of China(No82104166,N81730098 and N82030110);Medical Innovation Major Project(N916CXZo09);Shanghai Science and Technology Commission Project(N21140901000).
Aging is one of the main risk factors for cognitive dysfunction.During aging process,the decrease of brain-derived neurotrophic factor(BDNF)and the impairment of astrocyte function contribute to the cognitive impairme...
关键词：Metrnl AGING cognitive impairment BDNF HIPPOCAMPUS ASTROCYTES 
Gouqizi(Fructus Lycii)seed oil reduces D-galactose induced inflammation in testis of rats via Janus kinase 1/signal transducerand activator of transcription 1/nuclear factor-κB in vitro and in vivo
《Journal of Traditional Chinese Medicine》2023年第2期265-273,共9页YANG Zhangjie WANG Yuxin CHEN Dongmei ZHAO Shuai HU Na MA Lianghong MA Huiming 
Supported by Natural Science Foundation-funded Project:Activation of SIRT3 by Gouqizi(Fructus Lycii)Seed Oil to Improve Mitochondrial Function and Maintain Homeostasis in Injured Testis of Sub-acutely Aging Male Rats(No.81860876);Ningxia Natural Science Foundation-funded Project:Effects of Active Components of Gouqizi(Fructus Lycii)Seed Oil on Regulating Autophagy and Inflammation and Delaying Testicular Aging in Sub-acutely Aging Male Rats(No.2020AAC02016)。
OBJECTIVE:To investigate the efficacy of Gouqizi(Fructus Lycii)seed oil(FLSO)on D-gal induced inflammation in testis of rats in vitro and in vivo.METHODS:In aging Sertoli cells(TM4 cells)induced by D-galactose(D-gal),...
关键词：Gouqizi(Fructus Lycii) seed oil sertoli cells INFLAMMATION NF-kappa B 
Formulation Containing Phytosomes of Carotenoids from Nyctanthes arbor-tristis and Tagetes patula Protect D-galactose Induced Skin Aging in Mice
《Clinical Complementary Medicine and Pharmacology》2023年第1期35-46,共12页Archana Arvind Naik Chhaya Harihar Gadgoli Arvind Bhimrao Naik 
supported by National Medicinal Plant Board(NMPB),Dept.of Ayush,Government of India.(Project No.R&D/MS 04/2010).
Background:Carotenoids play important role in delay of aging process.Orange coloured tubular calyx of flowers of Nyctanthes arbor-tristis contains crocin,an apocarotenoid which forms a major component of stigma of saf...
关键词：AGING CROCIN Phytosomes Nyctanthes arbor-tristis Collagen Elastin Galactose induced aging 
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