Cross-talk between microRNAs,long non-coding RNAs and p21^(Cip1)in glioma:diagnostic,prognostic and therapeutic roles  

作　　者：Giorgio Santoni Maria Beatrice Morelli Massimo Nabissi Federica Maggi Oliviero Marinelli Matteo Santoni Consuelo Amantini 

机构地区：[1]School of Pharmacy,University of Camerino,Camerino 62032,Italy [2]Department of Molecular Medicine,University of Rome Sapienza,Rome 00161,Italy [3]Medical Oncology Unit,Hospital of Macerata,Macerata 62100,Italy [4]School of Biosciences and Veterinary Medicine,University of Camerino,Camerino 62032,Italy

出　　处：《Journal of Cancer Metastasis and Treatment》2020年第1期225-238,共14页癌症转移与治疗（英文版）

基　　金：PRIN 2017 and Fondazione Umberto Veronesi(Post-doctoral Fellowship 2019 to Morelli MB).

摘　　要：Glioblastoma multiforme is considered one of the most common malignant primary intracranial tumors.Despite treatment with a combination of surgery,chemotherapy and radiotherapy,patients with glioblastoma multiform have poor prognosis.It has been widely accepted that the occurrence,progression,and even recurrence of glioblastoma multiforme strictly depends on the presence of glioma cancer stem cells.The presence of glioma stem cells reduces the efficacy of standard therapies,thus increasing the imperative to identify new targets and therapeutic strategies in glioblastoma patients.In this regard,the p21^(Cip1)pathway has been found to play an important role in the maintenance of the glioma stem cells.It has been shown that this pathway regulates cancer stem cell pool by preventing hyperproliferation and exhaustion.MicroRNAs,endogenous small non-coding RNAs,and long non-coding RNAs,regulate post-transcription gene expression.These are not only altered in glioma,but also in other cancer types,and are involved in tumor development and progression.Notably,they have also been shown to modulate the expression of proteins in the p21^(Cip1)signaling pathway.This review highlights the extent and complexity of cross-talk between microRNAs,long non-coding RNAs and the p21^(Cip1)pathway,and demonstrates how such interplay orchestrates the regulation of protein expression and functions in glioma and glioma stem cells.

关 键 词：GLIOMA microRNA long non-coding RNA p21^(Cip1) glioma stem cells 

分 类 号：R73[医药卫生—肿瘤]