Perspective on dietary isothiocyanates in the prevention,development and treatment of cancer  

作　　者：Herman Yeger Reza Bayat Mokhtari 

机构地区：[1]The Hospital for Sick Children,Program in Developmental and Stem Cell Biology,Toronto,ON M5G 0A4,Canada [2]Department Biomedical&Molecular Sciences,Botterell Hall Rm 827,Queen’s University,Kingston,ON K7L 3N6,Canada

出　　处：《Journal of Cancer Metastasis and Treatment》2020年第1期271-286,共16页癌症转移与治疗（英文版）

摘　　要：Epidemiological evidence has highlighted the association of specific diets and a lower incidence of cancer.Foremost,the Mediterranean diet provides high levels of polyphenolics and a high consumption of healthier fats,e.g.,as from olive oil.In the Mediterranean region the consumption of vegetables is elevated providing a class of compounds,the isothiocyanates(ITCs)as found in the cabbage family.The ITCs have raised great interest for their health benefits over the past few decades.Some of the key ITC compounds,sulforaphane,phenethylisothiocyanate and benzyl isothiocyanate,have been studied in vitro and in vivo and the data support their promise for cancer chemoprevention,as anti-tumor agents,and for chemoprotection of normal tissues and organs.Along with other polyphenolic compounds in the diet,in general,they also possess key anti-inflammatory properties thus satisfying the criteria for compounds that could intervene in cancer initiation and progression.In this review we provide a larger overview of the advantages of including ITCs in the diet as food or as supplements and speculate on what could constitute a valuable therapeutic strategy for improving and sustaining good health and countering cancer disease in humans.

关 键 词：Mediterranean diet ISOTHIOCYANATES CHEMOPREVENTION CHEMOPROTECTION ANTI-TUMOR HORMESIS mitohormesis ANTI-INFLAMMATORY 

分 类 号：R73[医药卫生—肿瘤]