Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke  

作　　者：Rui Mao Ningning Zong Yujie Hu Ying Chen Yun Xu 

机构地区：[1]Department of Neurology,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing,210008,China [2]The State Key Laboratory of Pharmaceutical Biotechnology,Institute of Brain Science,Nanjing University,Nanjing,210008,China [3]Jiangsu Key Laboratory for Molecular Medicine,Medical School of Nanjing University,Nanjing,210008,China [4]Jiangsu Province Stroke Center for Diagnosis and Therapy,Nanjing,210008,China [5]Nanjing Neurology Clinic Medical Center,Nanjing,210008,China

出　　处：《Neuroscience Bulletin》2022年第10期1229-1247,共19页神经科学通报（英文版）

基　　金：This review was supported by the National Natural Science Foundation of China(81920108017,82130036,and 81630028);the Key Research and Development Program of Jiangsu Province of China(BE2020620);Jiangsu Province Key Medical Discipline(ZDXKA2016020).

摘　　要：Ischemic stroke caused by intracranial vascular occlusion has become increasingly prevalent with considerable mortality and disability,which gravely burdens the global economy.Current relatively effective clinical treatments are limited to intravenous alteplase and thrombectomy.Even so,patients still benefit little due to the short therapeutic window and the risk of ischemia/reperfusion injury.It is therefore urgent to figure out the neuronal death mechanisms following ischemic stroke in order to develop new neuroprotective strategies.Regarding the pathogenesis,multiple pathological events trigger the activation of cell death pathways.Particular attention should be devoted to excitotoxicity,oxidative stress,and inflammatory responses.Thus,in this article,we first review the principal mechanisms underlying neuronal death mediated by these significant events,such as intrinsic and extrinsic apoptosis,ferroptosis,parthanatos,pyroptosis,necroptosis,and autophagic cell death.Then,we further discuss the possibility of interventions targeting these pathological events and summarize the present pharmacological achievements.

关 键 词：Ischemic stroke Neuronal death MECHANISMS Therapeutic strategy 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]