Calcium Homeostasis in Parkinson’s Disease:From Pathology to Treatment  

作　　者：Jingxian Zhang Qingqing Shen Yue Ma Lin Liu Wenting Jia Leilei Chen Junxia Xie 

机构地区：[1]Institute of Brain Science and Disease,Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders,Qingdao University,Qingdao,266071,China

出　　处：《Neuroscience Bulletin》2022年第10期1267-1270,共4页神经科学通报（英文版）

基　　金：This insight was supported by the National Foundation of Natural Science of China(32170984);the Natural Science Foundation of Shandong Province(ZR2020YQ23 and ZR2019BC008).

摘　　要：Disturbances of Ca^(2+)homeostasis have been reported to be associated with the development of Parkinson's disease(PD)(Fig.1),which is characterized by the selective vulnerability of dopaminergic neurons in the substantia nigra pars compacta(SNpc).Different from the dopaminergic neurons in the ventral tegmental area(VTA),which mainly rely on hyperpolarization-activated cyclic nucleotide-gated/voltagegated channels for pacing and have a strong Ca^(2+)-buffering capacity.

关 键 词：HOMEOSTASIS STASIS capacity. 

分 类 号：R742.5[医药卫生—神经病学与精神病学]