NHERF1与NF2在结直肠癌组织中的表达及其临床意义  

Expression and Clinical Significance of NHERF1 and NF2 in Colorectal Cancer

作　　者：王治伟[1] 张友满 WANG Zhi-wei;ZHANG You-man(Department of General Surgery,Ankang Central Hospital,Ankang Shaanxi 725000)

机构地区：[1]安康市中心医院普通外科,陕西安康725000

出　　处：《医学临床研究》2022年第11期1672-1675,共4页Journal of Clinical Research

摘　　要：【目的】探讨Na+/H+交换器调节因子1(NHERF1)与神经纤维蛋白2基因(NF2)在结直肠癌组织中的表达及其临床意义。【方法】选取2015年3月至2016年6月安康市中心医院诊治的126例结直肠癌患者,收集结直肠癌组织及癌旁正常组织标本,采用免疫组化法检测结直肠癌组织及癌旁正常组织中NHERF1、NF2阳性表达情况,分析NHERF1、NF2阳性表达率与结直肠癌患者临床病理特征的关系;Cox比例风险回归模型分析结直肠癌患者预后的危险因素。【结果】结直肠癌组织中NHERF1阳性表达率为74.6%,显著高于癌旁正常组织的33.3%,NF2阳性表达率为28.6%,显著低于癌旁正常组织的77.8%,差异均有统计学意义(P<0.05)。NHERF1、NF2阳性表达率与年龄、性别无相关性(P>0.05);与肿瘤最大径、TNM分期、浸润深度、病理级别、淋巴结转移、复发相关(P<0.05)。肿瘤最大径≥2 cm、TNM分期Ⅲ~Ⅳ期、浸润深度≥1 cm、有淋巴血管浸润、病理级别高、有复发、NHERF1阳性、NF2阴性的结直肠癌患者5年生存率均显著降低(P<0.05)。TNM分期Ⅲ~Ⅳ期、病理级别高、NHERF1表达阳性、NF2表达阴性是结直肠癌患者预后的独立危险因素(P<0.05)。【结论】结直肠癌组织中NHERF1蛋白阳性表达率升高,NF2蛋白阳性表达降低;NHERF1阳性表达、NF2阴性表达是结直肠癌患者预后的独立危险因素。【Objective】Objective To investigate the expression and clinical significance of Na+/H+exchanger regulatory factor 1(NHERF1)and neurofibrin 2(NF2)gene in colorectal cancer.【Methods】A total of 126 colorectal cancer patients diagnosed and treated in Ankang Central Hospital from March 2015 to June 2016 were selected.Samples of colorectal cancer tissues and normal tissues adjacent to cancer were collected.The positive expression of NHERF1 and NF2 in colorectal cancer tissues and normal tissues adjacent to cancer was detected by immunohistochemistry,and the relationship between the positive expression rate of NHERF1 and NF2 and the clinicopathological characteristics of colorectal cancer patients was analyzed;Cox proportional hazard regression model was used to analyze the prognostic risk factors of colorectal cancer patients.【Results】The positive expression rate of NHERF1 in colorectal cancer was 74.6%,which was significantly higher than that in normal adjacent tissues(33.3%),and the positive expression rate of NF2 was 28.6%,which was significantly lower than that in normal adjacent tissues(77.8%,P<0.05).The positive rates of NHERF1 and NF2 were not correlated with age and sex(P>0.05);It was correlated with the maximum tumor diameter,TNM stage,depth of invasion,pathological grade,lymph node metastasis and recurrence(P<0.05).The 5-year survival rate of colorectal cancer patients with maximum tumor diameter≥2 cm,TNM stageⅢ-Ⅳ,depth of invasion≥1 cm,lymphatic vascular invasion,high pathological grade,recurrence,NHERF1 positive,NF2 negative were significantly reduced(P<0.05).TNM stageⅢ-Ⅳ,high pathological grade,positive expression of NHERF1 and negative expression of NF2 were independent risk factors for the prognosis of colorectal cancer patients(P<0.05).【Conclusion】The positive expression rate of NHERF1 protein in colorectal cancer is increased,while the positive expression of NF2 protein is decreased;NHERF1 positive expression and NF2 negative expression are independent risk factors for progn

关 键 词：结直肠肿瘤/病理学 基因 神经纤维瘤病2型 

分 类 号：R735.35[医药卫生—肿瘤]