溃疡性结肠炎动物模型的研究进展  

Research Progress on Animal Models of Ulcerative Colitis

作　　者：葛俊李 李芳 王春霞 颜春鲁 杨扶德 GE Junli;LI Fang;WANG Chunxia;YAN Chunlu;YANG Fude(College of pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China;College of Integrated Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730000 [2]甘肃中医药大学中西医结合学院,甘肃兰州730000

出　　处：《中华中医药学刊》2022年第11期165-170,I0040,共7页Chinese Archives of Traditional Chinese Medicine

基　　金：国家重点研发计划(2018YFC1706305);甘肃省教育厅产业支撑项目(2021CYZC-40)。

摘　　要：根据流行病学统计,溃疡性结肠炎(ulcerative colitis, UC)发病人数在国内外均呈上升趋势,且该疾病反复发作,部分患者会进一步发展为结肠癌,极大降低患者生活质量。目前,关于UC的作用机制研究尚无定论,临床治疗效果不理想,因此,简单、方便、有效的动物模型对于机制及治疗方法的研究具有重要意义。对化学模型和基因模型的诱导机制、影响因素、优缺点、造模方式以及UC临床表现、分子变化和组织变化做了详细综述。According to epidemiological statistics,the incidence of ulcerative colitis(UC)is on the rise both at home and abroad,and the disease occurs repeatedly,and some patients will further develop into colon cancer,greatly reducing the quality of life of patients.At present,there is no conclusion on the mechanism of UC,and the clinical treatment effect is not ideal.Therefore,a simple,convenient and effective animal model is of great significance for the study of mechanism and treatment.In this paper,the induction mechanism,influencing factors,advantages and disadvantages of chemical and gene models,as well as the clinical manifestations,molecular and tissue changes of UC were reviewed in detail.

关 键 词：溃疡性结肠炎 化学模型 基因模型 免疫诱导模型 中医病症模型 综述 

分 类 号：R-332[医药卫生]