Clusterin transduces Alzheimer-risk signals to amyloidogenesis  

作　　者：Xi Liu Rongbo Che Wenping Liang Yun Zhang Liyong Wu Chao Han Hong Lu Weihong Song Yili Wu Zhe Wang 

机构地区：[1]The National Clinical Research Center for Geriatric Disease,Department of Neurology,Advanced Innovation Center for Human Brain Protection,Xuanwu Hospital,Capital Medical University,Beijing,PR China [2]Department of Neurology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,PR China [3]Department of Psychiatry,Shandong Collaborative Innovation Center for Diagnosis,Treatment&Behavioral Interventions of Mental Disorders,Institute of Mental Health,Jining Medical University,Jining,Shandong,PR China [4]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Institute of Aging,Key Laboratory of Alzheimer’s Disease of Zhejiang Province,Zhejiang Provincial Clinical Research Center for Mental Disorders,School of Mental Health and The Affiliated Wenzhou Kangning Hospital,Wenzhou Medical University,Wenzhou,Zhejiang,PR China

出　　处：《Signal Transduction and Targeted Therapy》2022年第10期3658-3661,共4页信号转导与靶向治疗（英文）

基　　金：supported by National Natural Science Foundation of China(no.81870832);Beijing Committees of Education-Science Foundation of Beijing joint fund(no.KZ202010025040);“Wisdom Gathering”program of Xuanwu Hospital to Z.W.,National Natural Science Foundation of China(no.81771147 and 81971019);Y.W.,and National Natural Science Foundation of China(no.81600943)。

摘　　要：Dear Editor,Deposition of amyloid-β(Aβ)to form neuritic plaque(NP)is the hallmark of Alzheimer’s Disease(AD).Major non-genetic risk factors such as ageing,stroke,diabetes and other conditions facilitate AD pathogenesis via unclear mechanisms.Furthermore,the mechanism underlying NP formation is unclear.Increasing Aβcauses NP in familial AD patients and in transgenic AD mice robustly expressing Aβ,but the NP formation requires long-term Aβaccumulation.

关 键 词：ALZHEIMER AΒ CLUSTERIN 

分 类 号：R749.16[医药卫生—神经病学与精神病学]