Integration of multiscale entropy and BASED scale of electroencephalography after adrenocorticotropic hormone therapy predict relapse of infantile spasms  

作　　者：Lin Wan Chu-Ting Zhang Gang Zhu Jian Chen Xiu-Yu Shi Jing Wang Li-Ping Zou Bo Zhang Wen-Bin Shi Chien-Hung Yeh Guang Yang 

机构地区：[1]Senior Department of Pediatrics,Chinese PLA General Hospital,Beijing,100000,China [2]Department of Pediatrics,the First Medical Centre,Chinese PLA General Hospital,Beijing,China [3]Medical School of Chinese People’s Liberation Army,Beijing,China [4]School of Information and Electronics,Beijing Institute of Technology,Beijing,100081,China [5]The Second School of Clinical Medicine,Southern Medical University,Guangzhou,China [6]Department of Neurology and ICCTR Biostatistics and Research Design Center,Boston Children’s Hospital,Harvard Medical School,Boston,MA,USA

出　　处：《World Journal of Pediatrics》2022年第11期761-770,共10页世界儿科杂志（英文版）

基　　金：This research was partially supported by National Natural Science Foundation of China(Nos.62171028,62001026);the Natural Science Foundation of Beijing,China(No.7222187);the Medical Big Data and Artificial Intelligence Research and Development Project of the Chinese PLA General Hospital(No.2019MBD-004);the Epilepsy Research Fund of China Association Against Epilepsy(No.CU-B-2021-11);the Nutrition and Care of Maternal&Child Research Fund Project of Guangzhou Biostime Institute of Nutrition&Care(No.2021BINCMCF030).

摘　　要：Background Even though adrenocorticotropic hormone(ACTH)demonstrated powerful efficacy in the initially successful treatment of infantile spasms(IS),nearly half of patients have experienced a relapse.We sought to investigate whether features of electroencephalogram(EEG)predict relapse in those IS patients without structural brain abnormalities.Methods We retrospectively reviewed data from children with IS who achieved initial response after ACTH treatment,along with EEG recorded within the last two days of treatment.The recurrence of epileptic spasms following treatment was tracked for 12 months.Subjects were categorized as either non-relapse or relapse groups.General clinical and EEG recordings were collected,burden of amplitudes and epileptiform discharges(BASED)score and multiscale entropy(MSE)were carefully explored for cross-group comparisons.Results Forty-one patients were enrolled in the study,of which 26(63.4%)experienced a relapse.The BASED score was significantly higher in the relapse group.MSE in the non-relapse group was significantly lower than the relapse group in theγband but higher in the lower frequency range(δ,θ,α).Sensitivity and specificity were 85.71%and 92.31%,respectively,when combining MSE in theδ/γfrequency of the occipital region,plus BASED score were used to distinguish relapse from non-relapse groups.Conclusions BASED score and MSE of EEG after ACTH treatment could be used to predict relapse for IS patients without brain structural abnormalities.Patients with BASED score≥3,MSE increased in higher frequency,and decreased in lower frequency had a high risk of relapse.

关 键 词：Burden of amplitudes and epileptiform discharges score Infantile spasms Multiscale entropy Prediction RELAPSE 

分 类 号：R742.1[医药卫生—神经病学与精神病学]