枸杞子多糖不同组分的双向免疫调节机制研究进展  

Research Progress on the Dual-Directional Immunoregulatory Effect of Different Polysaccharide Fractions from Lycium barbarum Fruit

作　　者：田阳 龚桂萍 路宇 黄雯琪 李成 王仲孚 黄琳娟 TIAN Yang;GONG Guiping;LU Yu;HUANG Wenqi;LI Cheng;WANG Zhongfu;HUANG Linjuan(Shaanxi Natural Polysaccharide Resource Utilization Research Center,School of Food Science and Engineering,Northwest University,Xi’an 710062,China)

机构地区：[1]西北大学食品科学与工程学院,陕西省天然多糖资源利用研究中心,陕西西安710062

出　　处：《食品科学》2022年第23期356-366,共11页Food Science

基　　金：陕西省教育厅专项科研计划项目(21JK0929);陕西省科技厅科技资源开放共享平台项目(2022PT-46);陕西省榆林市科技局产学研项目(CXY-2021-128);陕西省创新能力支撑计划——科技创新团队项目(2020TD-044);国家自然科学基金青年科学基金项目(31901694)。

摘　　要：枸杞子多糖是枸杞中的主要功能成分,具有良好的免疫调节活性。现有研究大多关注枸杞子多糖的免疫促进功能,对其免疫抑制机制缺乏深入探索。因此,本文从肠黏膜保护、肠道菌群变化、免疫细胞和神经内分泌系统等方面,针对枸杞子多糖不同组分的免疫增强/抑制机制展开综述,为其在抗病毒治疗、抗肿瘤治疗、多种疫苗开发、动物饲料免疫增强配方和抗过敏药物/食品中的应用提供参考。Lycium barbarum polysaccharides(LBP) are one of the major functional components in the fruit of Lycium barbarum, which have been demonstrated to exert immunomodulatory activity. Most of the existing studies are focused on the immunoenhancing effect of LBP, but in-depth research on its immunosuppressive effect is limited. This article reviews recent research on the immunoenhancing and immunosuppressive effects of different polysaccharide fractions extracted from Lycium barbarum fruit from different perspectives, like intestinal mucosa protection, intestinal flora changes, immune cells and the neuroendocrine immune system. The outcome of this review will be for the application of Lycium barbarum polysaccharides in antiviral therapy, antitumor therapy, vaccine development, immune-enhancing feed formulation and antiallergic agents or food products.

关 键 词：枸杞子多糖 免疫调节 肠黏膜免疫 肠道菌群 免疫细胞 

分 类 号：TS201.4[轻工技术与工程—食品科学]