Multi-omics characterization and therapeutic liability of ferroptosis in melanoma  

作　　者：Yi He Yu Dong Yong Chen Guanxiong Zhang Hailun Zhang Guang Lei Yanhua Du Xiang Chen Youqiong Ye Hong Liu 

机构地区：[1]Department of Dermatology,Hunan Key Laboratory of Skin Cancer and Psoriasis,Hunan Engineering Research Center of Skin Health and Disease,Xiangya Clinical Research Center for Cancer Immunotherapy,Xiangya Hospital,Central South University,Changsha,China [2]Shanghai Institute of Immunology,Department of Immunology and Microbiology,Shanghai Jiao Tong University School of Medicine,Shanghai,China [3]Department of Musculoskeletal Surgery,Fudan University Shanghai Cancer Center,Shanghai,PR China [4]Department of Oncology,Shanghai Medical College,Fudan University,Shanghai,PR China [5]Department of Research and Development,Beijing GAP Biotechnology Co.,Ltd,Bejing,China [6]Department of Radiation Oncology,Hunan Cancer Hospital and The Affliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,China

出　　处：《Signal Transduction and Targeted Therapy》2022年第9期3194-3197,共4页信号转导与靶向治疗（英文）

基　　金：This study was supported by the National Key Research and Development Program of China(2019YFE0120800,2019YFA0111600);the Natural Science Foundation of China for outstanding Young Scholars(82022060);the National Natural Science Foundation of China(81874242,31800979,82073145);the Natural Science Foundation of Hunan Province for outstanding Young Scholars(2019J130040);the National Natural Science Foundation of China(62102455);China Postdoctoral Science Foundation(2020M682587).

摘　　要：Dear Editor,Ferroptosis,an iron-dependent form of programmed cell deathdriven by excessive lipid peroxidation,1has emerged as,apromising andeffective strategy fortrigering cancer celldeath.2,3Insufficient understanding of the role of ferroptosis in melanomaprogression and the tumor microenvironment(TME)has limitedthe development of ferroptosis-targeted therapy and combina-tions with other therapeutic strategies.

关 键 词：therapeutic MELANOMA PEROXIDATION 

分 类 号：R739.5[医药卫生—肿瘤]