硫酸化岩藻糖单糖的合成  

Synthesis of sulfated fucose monosaccharide

作　　者：全兴兴 杨劲松[1] QUAN Xingxing;YANG Jinsong(West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China)

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2022年第6期601-604,共4页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:21772132)。

摘　　要：目的制备硫酸化岩藻糖单糖。方法以C2-位羟基裸露、C3,4-位羟基异亚丙基缩醛保护的岩藻糖乙硫苷作为原料,经过2-亚甲基萘化、脱保护、氯硫酸异丁酯化等5步反应得到目标化合物Ⅰ。结果与结论收率49.8%,目标化合物Ⅰ的结构经^(1)HNMR、^(13)CNMR及HRMS(ESI)确证。该方法为含硫酸化岩藻糖化合物的合成奠定了基础。OBJECTIVE To prepare sulfation of fucose monosaccharide.METHODS C2-hydroxyl exposed and C3,4-isopropylene acetalde protected fucoidan ethylthioglycoside were used as raw material,and the target compoundⅠwas synthesized within 5 steps including 2-methylnaphthalene,deprotection and isobutyl chlorosulfate.RESULTS and CONCLUSION Sulfated fucoidan monosaccharideⅠwas obtained in 49.8%yield.The structure of the compound was confirmed by^(1)HNMR,CNMR and ^(13)HRMS(ESI),which lays the foundation for the synthesis of sulfur-containing acidified fucoidan compounds.

关 键 词：糖化学 岩藻糖 硫酸化 合成 保护基 核磁共振波谱 乙硫苷 单糖 

分 类 号：R914[医药卫生—药物化学]