卵巢无性细胞瘤临床表现及超声声像图特征  

Clinical and ultrasonographic features of ovarian dysgerminoma

作　　者：李柠肖 桂阳 莎仁高娃 王名法 刘艳超 吕珂 LI Ningxiao;GUI Yang;SHAREN Gaowa;WANG Mingfa;LIU Yanchao;LYU Ke(Department of Ultrasound,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Ultrasound,The Second Affiliated Hospital of Hainan Medical College,Haikou 570100,Hainan Province,China;Department of Health Management,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Pathology,The Second Affiliated Hospital of Hainan Medical College,Haikou 570100,Hainan Province,China;Department of Ultrasound,The Central Hospital of Handan,Handan 056000,Hebei Province,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院超声医学科,北京100730 [2]海南医学院第二附属医院超声医学科,海南海口570100 [3]中国医学科学院北京协和医学院北京协和医院健康医学部,北京100730 [4]海南医学院第二附属医院病理科,海南海口570100 [5]邯郸市中心医院超声医学科,河北邯郸056000

出　　处：《肿瘤影像学》2022年第6期561-566,共6页Oncoradiology

基　　金：中央高水平医院临床科研专项(2022-PUMCH-B-065);海南省卫生健康行业科研项目(21A200261);国家自然科学基金(81873902);中国医学科学院临床与转化医学研究(2020-I2M-C&T-B-039)。

摘　　要：目的:探讨卵巢无性细胞瘤的临床表现及超声声像图特征。方法:回顾并分析2017年7月—2020年12月于北京协和医院经手术治疗并经病理学检查证实为卵巢无性细胞瘤24例患者的超声表现及临床资料。结果:24例卵巢无性细胞瘤患者平均年龄(19.3±8.3)岁,87.5%(21/24)的患者为单侧病变。接受血清人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)检测者中85.7%(12/14)的血hCG水平升高(28~8660 U/L)。超声检查显示病灶共19例,平均最大径(14.7±6.2)cm,78.9%(15/19)呈分叶状,实性或以实性为主,边界清晰,68.4%(13/19)内可见高回声分隔及隔上见条形血流信号。29.2%(7/24)的患者为性腺发育不全,染色体核型均为46,XY型,其中71.4%(5/7)超声检查未明确显示病灶,包含双侧病变3例。结论:卵巢无性细胞瘤多为年轻患者的盆腔单侧病变,多伴有hCG水平升高,超声可显示附件区体积较大实性为主分叶状肿物,内部可见分隔回声及条形血流。性腺发育不全患者则可为双侧病变,且可能由于病灶较小而难以通过超声检查发现。Objective:To investigate the clinical and ultrasonographic features of ovarian dysgerminoma.Methods:From June 2017 to December 2020,the clinical characteristics and sonographic features of 24 cases with ovarian dysgerminoma surgically confirmed in Pecking Union Medical College Hospital were reviewed.Results:The medical records of 24 patients with ovarian dysgerminoma were reviewed.The average age was(19.3±8.3)years.87.5%(21/24)cases were unilateral.Elevated serum level of human chorionic gonadotropin(hCG)was observed in 85.7%(12/14)patients,ranging from 28 to 8660 U/L.29.2%(7/24)patients with gonadal dysgenesis,chromosome karyotypes were all 46,type XY.Among them,71.4%(5/7)lesions did not be showed by ultrasound clearly,including 3 bilateral lesions.19 lesions were showed by ultrasound in 19 cases,average maximum diameter was(14.7±6.2)cm,78.9%(15/19)were lobulated,mainly solid or solid,all had clear boundaries,high echo separation and partition bar flow signals visible in 68.4%(13/19).Conclusion:Ovarian dysgerminoma were mostly unilateral pelvic lesions in young women patients,which can be accompanied by elevated hCG level.Ovarian dysgerminoma has obvious ultrasonographic characteristics.Patients with gonadotic dysplasia can be bilateral lesions and may be difficult to detect through ultrasound due to small lesions.

关 键 词：卵巢无性细胞瘤 超声 性腺发育不全 

分 类 号：R737.31[医药卫生—肿瘤] R445.1[医药卫生—临床医学]