A novel chemotherapy strategy for advanced hepatocellular carcinoma: a multicenter retrospective study  

作　　者：Juxian Sun Chang Liu Jie Shi Nanya Wang Dafeng Jiang Feifei Mao Jingwen Gu Liping Zhou Li Shen Wan Yee Lau Shuqun Cheng 

机构地区：[1]Department of Hepatic Surgery VI,Eastern Hepatobiliary Surgery Hospital,The Second Military Medical University,Shanghai 200433,China [2]Department of Integrative Oncology,Eastern Hepatobiliary Surgery Hospital,The Second Military Medical University,Shanghai 200433,China [3]Department of Outpatient Department,Eastern Hepatobiliary Surgery Hospital,The Second Military Medical University,Shanghai 200433,China [4]Department of Oncology,First Hospital of Jlin University,Changchun,Jlin 1300,China [5]Department of Oncology Zhejiang Sian International Hospital,Jiaxing,Zhejang 314000,China [6]Tongji University Cancer Center,Shanghai Tenth People's Hospita,School of Medicine,Tongji Universit,Shanghai 200040,China [7]Faculty of Medicine,The Chinese University of Hong Kong,Prince of Wales Hospital,Shatin,New Territories,Hong Kong SAR 999077,China.

出　　处：《Chinese Medical Journal》2022年第19期2338-2343,共6页中华医学杂志（英文版）

基　　金：National Natural Science Foundation of China(No.82073293);Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center(Joint Project of Emerging Frontier Technology)(SHDC12018116);the Key Project of Natural Science Foundation of China(No:81730097)。

摘　　要：Background:Chemotherapy is a common treatment for advanced hepatocellular carcinoma,but the effect is not satisfactory.The study aimed to retrospectively evaluate the effects of adding all-trans-retinoic acid(ATRA)to infusional fluorouracil,leucovorin,and oxaliplatin(FOLFOX4)for advanced hepatocellular carcinoma(HCC).Methods:We extracted the data of patients with advanced HCC who underwent systemic chemotherapy using FOLFOX4 or ATRA plus FOLFOX4 at the Eastern Hepatobiliary Surgery Hospital,First Hospital of Jilin University,and Zhejiang Sian International Hospital and retrospectively compared for overall survival.The Cox proportional hazards model was used to calculate the hazard ratios for overall survival and disease progression after controlling for age,sex,and disease stage.Results:From July 2013 to July 2018,111 patients with HCC were included in this study.The median survival duration was 14.8 months in the ATRA plus FOLFOX4 group and 8.2 months in the FOLFOX4 only group(P<0.001).The ATRA plus FOLFOX4 group had a significantly longer median time to progression compared with the FOLFOX4 group(3.6 monthsvs.1.8 months,P<0.001).Hazard ratios for overall survival and disease progression were 0.465(95%confidence interval:0.298–0.726;P=0.001)and 0.474(0.314–0.717;P<0.001)after adjusting for potential confounders,respectively.Conclusion:ATRA plus FOLFOX4 significantly improves the overall survival and time to disease progression in patients with advanced HCC.

关 键 词：Hepatocellular carcinoma ATRA plus FOLFOX4 Overall survival All-trans-retinoic acid Fluorouracil LEUCOVORIN OXALIPLATIN 

分 类 号：R735.7[医药卫生—肿瘤]