Predictive value of N6-methyladenosine (m6A)-related genes for prognosis and correlation with tumor microenvironment in gastric cancer  

作　　者：Tengfei Yin Lang Zhao Shukun Yao 

机构地区：[1]Graduate School,Peking University China-Japan Friendship School of Clinical Medicine,Bejing 100029,China [2]Graduate Schol,Peking Union Medical College and Chinese Academy of Medical SCciences,Beijing 100730,China [3]Department of Gastroenterology,China-Japan Friendship Hospital,Bejing 100029,China

出　　处：《Chinese Medical Journal》2022年第19期2360-2362,共3页中华医学杂志（英文版）

基　　金：National Key Development Plan for Precision Medicine Research(No.2017YFC 0910002)。

摘　　要：To the Editor:Gastric cancer(GC)poses a great threat to human health worldwide.N6-methyladenosine(m6A)RNA methylation,the most abundant post-transcriptional RNA modification,plays a crucial role in RNA splicing,export,processing,translation,and decay.ii The tumor microenvironment(TME),an aggregation of tumor cells and surrounding tumor-related non-tumor cells,innately modulates tumor progression,21However,the prognostic value of m6A regulator-related genes and their relationship with the TME have not been largely explored in GC.The aim of our study was to screen prognostic genes related to m6A modification in GC patients in The Cancer Genome Atlas(TCGA)database,establish an m6A regulatorassociated signature for predicting clinical outcome,and validate the performance in TCGA and Gene Expression Omnibus(GEO)cohorts.The relationship between m6A and immune infiltration was also assessed in GC.With the underlyingmechanismuncovered,m6A-relatedgenescould become predictive biomarkers for GC and provide deeper insights into the TME and immunotherapy.

关 键 词：CANCER GASTRIC VALUE 

分 类 号：R735.2[医药卫生—肿瘤]