Klotho基因与认知障碍相关性的研究进展  

Research progress on the correlation between Klotho gene and cognitive impairment

作　　者：徐敏[1] 杨兰青 仲喆 叶民[1] Xu Min;Yang Lanqing;Zhong Zhe;Ye Min(Department of Neurology,the Affiliated BenQ Hospital of Nanjing Medical University,Nanjing 210019,China)

机构地区：[1]南京医科大学附属明基医院神经内科,210019

出　　处：《神经疾病与精神卫生》2022年第11期833-836,共4页Journal of Neuroscience and Mental Health

摘　　要：Klotho基因是抗衰老基因,其编码的Klotho蛋白具有抵抗衰老、延长寿命的作用,与认知功能息息相关。Klotho蛋白在如阿尔茨海默病、帕金森病、额颞叶痴呆等神经变性病认知障碍以及血管性认知障碍中均发挥重要作用,通过诸如缓解β淀粉样蛋白负担、减轻炎性反应、抵抗氧化应激等方式保护认知功能。现总结国内外关于Klotho基因、Klotho蛋白与各型认知障碍的研究进展,旨在为该领域的研究提供理论依据。The Klotho gene is an anti-aging gene, and the Klotho encoded protein has the effect of antiaging and prolonging lifespan, which is closely related to cognitive function. Klotho protein plays an important role in cognitive impairment of neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and frontotemporal dementia, and vascular cognitive impairment. It can protect cognitive function by such means as mitigation β-amyloid protein burden, reduce inflammatory reaction, resist oxidative stress and other ways. This paper summarizes the current research progress on Klotho gene, Klotho protein and various types of cognitive impairment at home and abroad, in order to provide a theoretical basis for the research in this field.

关 键 词：认知障碍 KLOTHO基因 神经变性病 血管性认知障碍 综述 

分 类 号：R749.1[医药卫生—神经病学与精神病学]